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10.1038/srep26740 http://scihub22266oqcxt.onion/10.1038/srep26740 C4879671!4879671 !27221338     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27221338 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 26740 Nephropedia Template TP {{tp|p=27221338 |t=2016. C-Reactive Protein Promotes Diabetic Kidney Disease in db/db Mice via the CD32b-Smad3-mTOR signaling Pathway |pdf=|usr=}}{{27221338 }} gab.com Text C-Reactive Protein Promotes Diabetic Kidney Disease in db/db Mice via the CD32b-Smad3-mTOR signaling Pathway JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27221338 #FOAvip C-reactive protein (CRP) is associated with progressive diabetic nephropathy in patients with type-2 diabetes (T2DN). However, role of CRP in T2DN remains unclear. We report here that CRP is pathogenic in T2DN in db/db mice that express human CRP (CRPtg-db/db). Compared to the littermate db/db mice, CRPtg-db/db developed more severe T2DN, showing higher levels of fasting blood glucose and microalbuminuria and more progressive renal inflammation and fibrosis. Enhanced T2DN in CRPtg-db/db mice were associated with over-activation of CRP-CD32b, NF-?B, TGF-?/Smad3, and mTOR signaling. Further studies in vitro defined that CRP activated Smad3 directly at 15?mins via the CD32b- ERK/p38 MAP kinase crosstalk pathway and indirectly at 24?hours through a TGF-?1-dependent mechanism. Importantly, CRP also activated mTOR signaling at 30?mins via a Smad3-dependent mechanism as Smad3 bound mTOR physically and CRP-induced mTOR signaling was abolished by a neutralizing CD32b antibody and a specific Smad3 inhibitor. Finally, we also found that CRP induced renal fibrosis through a CD32b-Smad3-mTOR pathway because blocking mTOR signaling with rapamycin inhibited CRP-induced CTGF and collagen I expression. Thus, CRP is pathogenic in T2DN. CRP may promote CD32b- NF-?B signaling to mediate renal inflammation; whereas, CRP may enhance renal fibrosis in T2DN via CD32b-Smad3-mTOR signaling. Twit Text FOAVip C-Reactive Protein Promotes Diabetic Kidney Disease in db/db Mice via the CD32b-Smad3-mTOR signaling Pathway ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27221338 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27221338 #FOAvip English Wikipedia <ref>{{Cite pmid|27221338 }}</ref> C-Reactive Protein Promotes Diabetic Kidney Disease in db/db Mice via the CD32b-Smad3-mTOR signaling Pathway #MMPMID27221338 You YK ; Huang XR ; Chen HY ; Lyu XF ; Liu HF ; Lan HY Sci Rep 2016[May]; 6 (ä): 26740 PMID27221338 show ga C-reactive protein (CRP) is associated with progressive diabetic nephropathy in patients with type-2 diabetes (T2DN). However, role of CRP in T2DN remains unclear. We report here that CRP is pathogenic in T2DN in db/db mice that express human CRP (CRPtg-db/db). Compared to the littermate db/db mice, CRPtg-db/db developed more severe T2DN, showing higher levels of fasting blood glucose and microalbuminuria and more progressive renal inflammation and fibrosis. Enhanced T2DN in CRPtg-db/db mice were associated with over-activation of CRP-CD32b, NF-?B, TGF-?/Smad3, and mTOR signaling. Further studies in vitro defined that CRP activated Smad3 directly at 15?mins via the CD32b- ERK/p38 MAP kinase crosstalk pathway and indirectly at 24?hours through a TGF-?1-dependent mechanism. Importantly, CRP also activated mTOR signaling at 30?mins via a Smad3-dependent mechanism as Smad3 bound mTOR physically and CRP-induced mTOR signaling was abolished by a neutralizing CD32b antibody and a specific Smad3 inhibitor. Finally, we also found that CRP induced renal fibrosis through a CD32b-Smad3-mTOR pathway because blocking mTOR signaling with rapamycin inhibited CRP-induced CTGF and collagen I expression. Thus, CRP is pathogenic in T2DN. CRP may promote CD32b- NF-?B signaling to mediate renal inflammation; whereas, CRP may enhance renal fibrosis in T2DN via CD32b-Smad3-mTOR signaling. |*Signal Transduction [MESH] |Animals [MESH] |C-Reactive Protein/genetics/*metabolism [MESH] |Diabetes Mellitus, Experimental/genetics/*metabolism [MESH] |Diabetes Mellitus, Type 2/genetics/*metabolism [MESH] |Diabetic Nephropathies/genetics/*metabolism [MESH] |Male [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Receptors, IgG/genetics/*metabolism [MESH] |Smad3 Protein/genetics/*metabolism [MESH]C-Reactive Protein Promotes Diabetic Kidney Disease in db/db Mice via (epmc).pdf DeepDyve Pubget Overpricing