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10.1038/srep26838 http://scihub22266oqcxt.onion/10.1038/srep26838 C4879570!4879570!27220684     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27220684&cmd=llinks): Failed to open stream: HTTP request failed! 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Open and closed evolutionary paths for drastic morphological changes, involving serial gene duplication, sub-functionalization, and selection |pdf=|usr=}}{{27220684}} gab.com Text Open and closed evolutionary paths for drastic morphological changes, involving serial gene duplication, sub-functionalization, and selection JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27220684 #FOAvip Twin-tail goldfish strains are examples of drastic morphological alterations that emerged through domestication. Although this mutation is known to be caused by deficiency of one of two duplicated chordin genes, it is unknown why equivalent mutations have not been observed in other domesticated fish species. Here, we compared the chordin gene morphant phenotypes of single-tail goldfish and common carp (close relatives, both of which underwent chordin gene duplication and domestication). Morpholino-induced knockdown depleted chordin gene expression in both species; however, while knockdown reproduced twin-tail morphology in single-tail goldfish, it had no effect on common carp morphology. This difference can be explained by the observation that expression patterns of the duplicated chordin genes overlap completely in common carp, but are sub-functionalized in goldfish. Our finding implies that goldfish drastic morphological changes might be enhanced by the subsequent occurrence of three different types of evolutionary event (duplication, sub-functionalization, and selection) in a certain order. Twit Text FOAVip Open and closed evolutionary paths for drastic morphological changes, involving serial gene duplication, sub-functionalization, and selection ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27220684 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27220684 #FOAvip English Wikipedia <ref>{{Cite pmid|27220684}}</ref> Open and closed evolutionary paths for drastic morphological changes, involving serial gene duplication, sub-functionalization, and selection #MMPMID27220684 Abe G; Lee SH; Li IJ; Chang CJ; Tamura K; Ota KG Sci Rep 2016[]; 6 (ä): ä PMID27220684show ga Twin-tail goldfish strains are examples of drastic morphological alterations that emerged through domestication. Although this mutation is known to be caused by deficiency of one of two duplicated chordin genes, it is unknown why equivalent mutations have not been observed in other domesticated fish species. Here, we compared the chordin gene morphant phenotypes of single-tail goldfish and common carp (close relatives, both of which underwent chordin gene duplication and domestication). Morpholino-induced knockdown depleted chordin gene expression in both species; however, while knockdown reproduced twin-tail morphology in single-tail goldfish, it had no effect on common carp morphology. This difference can be explained by the observation that expression patterns of the duplicated chordin genes overlap completely in common carp, but are sub-functionalized in goldfish. Our finding implies that goldfish drastic morphological changes might be enhanced by the subsequent occurrence of three different types of evolutionary event (duplication, sub-functionalization, and selection) in a certain order. äOpen and closed evolutionary paths for drastic morphological changes, (epmc).pdf DeepDyve Pubget Overpricing