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10.1038/ncomms11624 http://scihub22266oqcxt.onion/10.1038/ncomms11624 C4879264!4879264 !27211851     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27211851 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2016 ; 7 (ä): 11624 Nephropedia Template TP {{tp|p=27211851 |t=2016. Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription |pdf=|usr=}}{{27211851 }} gab.com Text Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27211851 #FOAvip Nrf2 (NF-E2-related factor-2) transcription factor regulates oxidative/xenobiotic stress response and also represses inflammation. However, the mechanisms how Nrf2 alleviates inflammation are still unclear. Here, we demonstrate that Nrf2 interferes with lipopolysaccharide-induced transcriptional upregulation of proinflammatory cytokines, including IL-6 and IL-1?. Chromatin immunoprecipitation (ChIP)-seq and ChIP-qPCR analyses revealed that Nrf2 binds to the proximity of these genes in macrophages and inhibits RNA Pol II recruitment. Further, we found that Nrf2-mediated inhibition is independent of the Nrf2-binding motif and reactive oxygen species level. Murine inflammatory models further demonstrated that Nrf2 interferes with IL6 induction and inflammatory phenotypes in vivo. Thus, contrary to the widely accepted view that Nrf2 suppresses inflammation through redox control, we demonstrate here that Nrf2 opposes transcriptional upregulation of proinflammatory cytokine genes. This study identifies Nrf2 as the upstream regulator of cytokine production and establishes a molecular basis for an Nrf2-mediated anti-inflammation approach. Twit Text FOAVip Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27211851 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27211851 #FOAvip English Wikipedia <ref>{{Cite pmid|27211851 }}</ref> Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription #MMPMID27211851 Kobayashi EH ; Suzuki T ; Funayama R ; Nagashima T ; Hayashi M ; Sekine H ; Tanaka N ; Moriguchi T ; Motohashi H ; Nakayama K ; Yamamoto M Nat Commun 2016[May]; 7 (ä): 11624 PMID27211851 show ga Nrf2 (NF-E2-related factor-2) transcription factor regulates oxidative/xenobiotic stress response and also represses inflammation. However, the mechanisms how Nrf2 alleviates inflammation are still unclear. Here, we demonstrate that Nrf2 interferes with lipopolysaccharide-induced transcriptional upregulation of proinflammatory cytokines, including IL-6 and IL-1?. Chromatin immunoprecipitation (ChIP)-seq and ChIP-qPCR analyses revealed that Nrf2 binds to the proximity of these genes in macrophages and inhibits RNA Pol II recruitment. Further, we found that Nrf2-mediated inhibition is independent of the Nrf2-binding motif and reactive oxygen species level. Murine inflammatory models further demonstrated that Nrf2 interferes with IL6 induction and inflammatory phenotypes in vivo. Thus, contrary to the widely accepted view that Nrf2 suppresses inflammation through redox control, we demonstrate here that Nrf2 opposes transcriptional upregulation of proinflammatory cytokine genes. This study identifies Nrf2 as the upstream regulator of cytokine production and establishes a molecular basis for an Nrf2-mediated anti-inflammation approach. |*Gene Expression Regulation [MESH] |Animals [MESH] |Cytokines/*metabolism [MESH] |Inflammation/*metabolism [MESH] |Macrophages/*metabolism [MESH] |Mice, Inbred C57BL [MESH] |Mice, Inbred ICR [MESH] |Mice, Knockout [MESH] |NF-E2-Related Factor 2/*metabolism [MESH] |Oxidative Stress [MESH]Nrf2 suppresses macrophage inflammatory response by blocking proinflam(epmc).pdf DeepDyve Pubget Overpricing