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10.1007/s11888-016-0312-y http://scihub22266oqcxt.onion/10.1007/s11888-016-0312-y C4879165!4879165!27340376     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27340376&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Colorectal+Cancer+Rep 2016 ; 12 (ä): 141-50 Nephropedia Template TP {{tp|p=27340376|t=2016. Molecular Subtypes and Personalized Therapy in Metastatic Colorectal Cancer |pdf=|usr=}}{{27340376}} gab.com Text Molecular Subtypes and Personalized Therapy in Metastatic Colorectal Cancer JO: Curr Colorectal Cancer Rep http://www.kidney.de/pget.php?&tw=1&pmid=27340376 #FOAvip Development of colorectal cancer occurs via a number of key pathways, with the clinicopathological features of specific subgroups being driven by underlying molecular changes. Mutations in key genes within the network of signalling pathways have been identified; however, therapeutic strategies to target these aberrations remain limited. As understanding of the biology of colorectal cancer has improved, this has led to a move toward broader genomic testing, collaborative research and innovative, adaptive clinical trial design. Recent developments in therapy include the routine adoption of wider mutational spectrum testing prior to use of targeted therapies and the first promise of effective immunotherapy for colorectal cancer patients. This review details current biomarkers in colorectal cancer for molecular stratification and for treatment allocation purposes, including open and planned precision medicine trials. Advances in our understanding, therapeutic strategy and technology will also be outlined. Twit Text FOAVip Molecular Subtypes and Personalized Therapy in Metastatic Colorectal Cancer ????Curr Colorectal Cancer Rep http://www.kidney.de/pget.php?&tw=1&pmid=27340376 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27340376 #FOAvip English Wikipedia <ref>{{Cite pmid|27340376}}</ref> Molecular Subtypes and Personalized Therapy in Metastatic Colorectal Cancer #MMPMID27340376 Graham DM; Coyle VM; Kennedy RD; Wilson RH Curr Colorectal Cancer Rep 2016[]; 12 (ä): 141-50 PMID27340376show ga Development of colorectal cancer occurs via a number of key pathways, with the clinicopathological features of specific subgroups being driven by underlying molecular changes. Mutations in key genes within the network of signalling pathways have been identified; however, therapeutic strategies to target these aberrations remain limited. As understanding of the biology of colorectal cancer has improved, this has led to a move toward broader genomic testing, collaborative research and innovative, adaptive clinical trial design. Recent developments in therapy include the routine adoption of wider mutational spectrum testing prior to use of targeted therapies and the first promise of effective immunotherapy for colorectal cancer patients. This review details current biomarkers in colorectal cancer for molecular stratification and for treatment allocation purposes, including open and planned precision medicine trials. Advances in our understanding, therapeutic strategy and technology will also be outlined. äMolecular Subtypes and Personalized Therapy in Metastatic Colorectal C(epmc).pdf DeepDyve Pubget Overpricing