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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Mol+Psychiatry 2016 ; 21 (10): 1434-40 Nephropedia Template TP
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Linkage and association analysis of ADHD endophenotypes in extended and multigenerational pedigrees from a genetic isolate #MMPMID26598068
Mastronardi CA; Pillai E; Pineda DA; Martinez AF; Lopera F; Velez JI; Palacio JD; Patel H; Easteal S; Acosta MT; Castellanos FX; Muenke M; Arcos-Burgos M
Mol Psychiatry 2016[Oct]; 21 (10): 1434-40 PMID26598068show ga
Attention-deficit/hyperactivity disorder (ADHD) is a heritable, chronic, neurodevelopmental disorder with serious long-term repercussions. Despite being one of the most common cognitive disorders, the clinical diagnosis of ADHD is based on subjective assessments of perceived behaviors. Endophenotypes (neurobiological markers that cosegregate and are associated with an illness) are thought to provide a more powerful and objective framework for revealing the underlying neurobiology than syndromic psychiatric classification. Here, we present the results of applying genetic linkage and association analyses to neuropsychological endophenotypes using microsatellite and single nucleotide polymorphisms. We found several new genetic regions linked and/or associated with these endophenotypes, and others previously associated to ADHD, for example, loci harbored in the LPHN3, FGF1, POLR2A, CHRNA4 and ANKFY1 genes. These findings, when compared with those linked and/or associated to ADHD, suggest that these endophenotypes lie on shared pathways. The genetic information provided by this study offers a novel and complementary method of assessing the genetic causes underpinning the susceptibility to behavioral conditions and may offer new insights on the neurobiology of the disorder.