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10.1038/nmat4570 http://scihub22266oqcxt.onion/10.1038/nmat4570 C4879054!4879054!26950595     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Mater 2016 ; 15 (6): 669-78 Nephropedia Template TP {{tp|p=26950595|t=2016. Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis |pdf=|usr=}}{{26950595}} gab.com Text Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis JO: Nat Mater http://www.kidney.de/pget.php?&tw=1&pmid=26950595 #FOAvip We report the fabrication of a scaffold (hereafter referred to as AngioChip) that supports the assembly of parenchymal cells on a mechanically tunable matrix surrounding a perfusable, branched, three-dimensional microchannel network coated with endothelial cells. The design of AngioChip decouples the material choices for the engineered vessel network and for cell seeding in the parenchyma, enabling extensive remodelling while maintaining an open-vessel lumen. The incorporation of nanopores and micro-holes in the vessel walls enhances permeability, and permits intercellular crosstalk and extravasation of monocytes and endothelial cells on biomolecular stimulation. We also show that vascularized hepatic tissues and cardiac tissues engineered by using AngioChips process clinically relevant drugs delivered through the vasculature, and that millimeter-thick cardiac tissues can be engineered in a scalable manner. Moreover, we demonstrate that AngioChip cardiac tissues implanted via direct surgical anastomosis to the femoral vessels of rat hindlimbs establish immediate blood perfusion. Twit Text FOAVip Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis ????Nat Mater http://www.kidney.de/pget.php?&tw=1&pmid=26950595 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26950595 #FOAvip English Wikipedia <ref>{{Cite pmid|26950595}}</ref> Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis #MMPMID26950595 Zhang B; Montgomery M; Chamberlain MD; Ogawa S; Korolj A; Pahnke A; Wells LA; Massé S; Kim J; Reis L; Momen A; Nunes SS; Wheeler A; Nanthakumar K; Keller G; Sefton MV; Radisic M Nat Mater 2016[Jun]; 15 (6): 669-78 PMID26950595show ga We report the fabrication of a scaffold (hereafter referred to as AngioChip) that supports the assembly of parenchymal cells on a mechanically tunable matrix surrounding a perfusable, branched, three-dimensional microchannel network coated with endothelial cells. The design of AngioChip decouples the material choices for the engineered vessel network and for cell seeding in the parenchyma, enabling extensive remodelling while maintaining an open-vessel lumen. The incorporation of nanopores and micro-holes in the vessel walls enhances permeability, and permits intercellular crosstalk and extravasation of monocytes and endothelial cells on biomolecular stimulation. We also show that vascularized hepatic tissues and cardiac tissues engineered by using AngioChips process clinically relevant drugs delivered through the vasculature, and that millimeter-thick cardiac tissues can be engineered in a scalable manner. Moreover, we demonstrate that AngioChip cardiac tissues implanted via direct surgical anastomosis to the femoral vessels of rat hindlimbs establish immediate blood perfusion. äBiodegradable scaffold with built-in vasculature for organ-on-a-chip e(epmc).pdf DeepDyve Pubget Overpricing