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10.1038/nmat4570 http://scihub22266oqcxt.onion/10.1038/nmat4570 C4879054!4879054 !26950595     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26950595 &cmd=llinks): Failed to open stream: HTTP request failed! 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Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis |pdf=|usr=}}{{26950595 }} gab.com Text Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis JO: Nat Mater http://www.kidney.de/pget.php?&tw=1&pmid=26950595 #FOAvip We report the fabrication of a scaffold (hereafter referred to as AngioChip) that supports the assembly of parenchymal cells on a mechanically tunable matrix surrounding a perfusable, branched, three-dimensional microchannel network coated with endothelial cells. The design of AngioChip decouples the material choices for the engineered vessel network and for cell seeding in the parenchyma, enabling extensive remodelling while maintaining an open-vessel lumen. The incorporation of nanopores and micro-holes in the vessel walls enhances permeability, and permits intercellular crosstalk and extravasation of monocytes and endothelial cells on biomolecular stimulation. We also show that vascularized hepatic tissues and cardiac tissues engineered by using AngioChips process clinically relevant drugs delivered through the vasculature, and that millimetre-thick cardiac tissues can be engineered in a scalable manner. Moreover, we demonstrate that AngioChip cardiac tissues implanted with direct surgical anastomosis to the femoral vessels of rat hindlimbs establish immediate blood perfusion. Twit Text FOAVip Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis ????Nat Mater http://www.kidney.de/pget.php?&tw=1&pmid=26950595 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26950595 #FOAvip English Wikipedia <ref>{{Cite pmid|26950595 }}</ref> Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis #MMPMID26950595 Zhang B ; Montgomery M ; Chamberlain MD ; Ogawa S ; Korolj A ; Pahnke A ; Wells LA ; Massé S ; Kim J ; Reis L ; Momen A ; Nunes SS ; Wheeler AR ; Nanthakumar K ; Keller G ; Sefton MV ; Radisic M Nat Mater 2016[Jun]; 15 (6 ): 669-78 PMID26950595 show ga We report the fabrication of a scaffold (hereafter referred to as AngioChip) that supports the assembly of parenchymal cells on a mechanically tunable matrix surrounding a perfusable, branched, three-dimensional microchannel network coated with endothelial cells. The design of AngioChip decouples the material choices for the engineered vessel network and for cell seeding in the parenchyma, enabling extensive remodelling while maintaining an open-vessel lumen. The incorporation of nanopores and micro-holes in the vessel walls enhances permeability, and permits intercellular crosstalk and extravasation of monocytes and endothelial cells on biomolecular stimulation. We also show that vascularized hepatic tissues and cardiac tissues engineered by using AngioChips process clinically relevant drugs delivered through the vasculature, and that millimetre-thick cardiac tissues can be engineered in a scalable manner. Moreover, we demonstrate that AngioChip cardiac tissues implanted with direct surgical anastomosis to the femoral vessels of rat hindlimbs establish immediate blood perfusion. |*Lab-On-A-Chip Devices [MESH] |*Tissue Engineering/instrumentation/methods [MESH] |Anastomosis, Surgical [MESH] |Animals [MESH] |Biocompatible Materials/*chemistry [MESH] |Femur/blood supply/cytology/metabolism [MESH] |Human Umbilical Vein Endothelial Cells/cytology/*metabolism [MESH] |Humans [MESH] |Liver/blood supply/cytology/*metabolism [MESH] |Monocytes/cytology/*metabolism [MESH] |Myocardium/*cytology/metabolism [MESH] |Porosity [MESH] |Rats [MESH] |Rats, Inbred Lew [MESH]Biodegradable scaffold with built-in vasculature for organ-on-a-chip e(epmc).pdf DeepDyve Pubget Overpricing