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2013 ; 72
(ä): 313-46
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Curr Top Membr
2013[]; 72
(ä): 313-46
PMID24210434
show ga
The immunological synapse (IS) is an excellent example of cell-cell
communication, where signals are exchanged between two cells, resulting in a
well-structured line of defense during adaptive immune response. This process has
been the focus of several studies that aimed at understanding its formation and
subsequent events and has led to the realization that it relies on a
well-orchestrated molecular program that only occurs when specific requirements
are met. The development of more precise and controllable T cell activation
systems has led to new insights including the role of mechanotransduction in the
process of formation of the IS and T cell activation. Continuous advances in our
understanding of the IS formation, particularly in the context of T cell
activation and differentiation, as well the development of new T cell activation
systems are being applied to the establishment and improvement of immune
therapeutical approaches.