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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cell 2016 ; 165 (5): 1055-66 Nephropedia Template TP
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A Structure and Dynamics Continuum of Higher-Order Assemblies: Amyloids, Signalosomes and Granules #MMPMID27203110
Wu H; Fuxreiter M
Cell 2016[May]; 165 (5): 1055-66 PMID27203110show ga
We here attempt to reach an integrated understanding of the structure and dynamics of a number of higher-order assemblies including amyloids, various kinds of signalosomes, and cellular granules. We propose that the synergy between folded domains, linear motifs and intrinsically disordered regions regulates formation and intrinsic fuzziness of all higher-order assemblies, creating a structural and dynamic continuum. We describe how such regulatory mechanisms could be influenced under pathological conditions.