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10.1016/j.cell.2016.05.004

http://scihub22266oqcxt.onion/10.1016/j.cell.2016.05.004
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C4878688!4878688!27203110
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suck abstract from ncbi


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pmid27203110      Cell 2016 ; 165 (5): 1055-66
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  • A Structure and Dynamics Continuum of Higher-Order Assemblies: Amyloids, Signalosomes and Granules #MMPMID27203110
  • Wu H; Fuxreiter M
  • Cell 2016[May]; 165 (5): 1055-66 PMID27203110show ga
  • We here attempt to reach an integrated understanding of the structure and dynamics of a number of higher-order assemblies including amyloids, various kinds of signalosomes, and cellular granules. We propose that the synergy between folded domains, linear motifs and intrinsically disordered regions regulates formation and intrinsic fuzziness of all higher-order assemblies, creating a structural and dynamic continuum. We describe how such regulatory mechanisms could be influenced under pathological conditions.
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