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10.3892/mmr.2016.5186 http://scihub22266oqcxt.onion/10.3892/mmr.2016.5186 C4878563!4878563 !27121797     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27121797 &cmd=llinks): Failed to open stream: HTTP request failed! 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P?selectin increases angiotensin II?induced cardiac inflammation and fibrosis via platelet activation |pdf=|usr=}}{{27121797 }} gab.com Text P selectin increases angiotensin II induced cardiac inflammation and fibrosis via platelet activation JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=27121797 #FOAvip Platelet activation is important in hypertension?induced cardiac inflammation and fibrosis. P-selectin expression significantly (P<0.05) increases when platelets are activated during hypertension. Although P?selectin recruits leukocytes to sites of inflammation, the role of P?selectin in cardiac inflammation and fibrosis remains to be elucidated. The present study aimed to investigate whether platelet?derived P?selectin promotes hypertensive cardiac inflammation and fibrosis. P?selectin knockout (P?sel KO) mice and wild?type (WT) C57BL/6 littermates were infused with angiotensin II (Ang II) at 1,500 ng/kg/min for 7 days and then cross?transplanted with platelets originating from either WT or P?sel KO mice. P?selectin expression was increased in the myocardium and plasma of hypertensive mice, and the P?sel KO mice exhibited significantly (P<0.05) reduced cardiac fibrosis. The fibrotic areas were markedly smaller in the hearts of P?sel KO mice compared with WT mice, as assessed by Masson's trichrome staining. In addition, ??smooth muscle actin and transforming growth factor ?1 (TGF??1) expression levels were decreased in the P?sel KO mice, as assessed by immunohistochemistry. Following platelet transplantation into P?sel KO mice, the number of Mac?2 (galectin?3)? and TGF??1?positive cells was increased in mice that received WT platelets compared with those that received P?sel KO platelets, and the mRNA expression levels of collagen I and TGF??1 were also increased. The results from the present study suggest that activated platelets secrete P?selectin to promote cardiac inflammation and fibrosis in Ang II?induced hypertension. Twit Text FOAVip P selectin increases angiotensin II induced cardiac inflammation and fibrosis via platelet activation ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=27121797 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27121797 #FOAvip English Wikipedia <ref>{{Cite pmid|27121797 }}</ref> P?selectin increases angiotensin II?induced cardiac inflammation and fibrosis via platelet activation #MMPMID27121797 Liu G ; Liang B ; Song X ; Bai R ; Qin W ; Sun X ; Lu Y ; Bian Y ; Xiao C Mol Med Rep 2016[Jun]; 13 (6 ): 5021-8 PMID27121797 show ga Platelet activation is important in hypertension?induced cardiac inflammation and fibrosis. P-selectin expression significantly (P<0.05) increases when platelets are activated during hypertension. Although P?selectin recruits leukocytes to sites of inflammation, the role of P?selectin in cardiac inflammation and fibrosis remains to be elucidated. The present study aimed to investigate whether platelet?derived P?selectin promotes hypertensive cardiac inflammation and fibrosis. P?selectin knockout (P?sel KO) mice and wild?type (WT) C57BL/6 littermates were infused with angiotensin II (Ang II) at 1,500 ng/kg/min for 7 days and then cross?transplanted with platelets originating from either WT or P?sel KO mice. P?selectin expression was increased in the myocardium and plasma of hypertensive mice, and the P?sel KO mice exhibited significantly (P<0.05) reduced cardiac fibrosis. The fibrotic areas were markedly smaller in the hearts of P?sel KO mice compared with WT mice, as assessed by Masson's trichrome staining. In addition, ??smooth muscle actin and transforming growth factor ?1 (TGF??1) expression levels were decreased in the P?sel KO mice, as assessed by immunohistochemistry. Following platelet transplantation into P?sel KO mice, the number of Mac?2 (galectin?3)? and TGF??1?positive cells was increased in mice that received WT platelets compared with those that received P?sel KO platelets, and the mRNA expression levels of collagen I and TGF??1 were also increased. The results from the present study suggest that activated platelets secrete P?selectin to promote cardiac inflammation and fibrosis in Ang II?induced hypertension. |*Platelet Activation [MESH] |Angiotensin II/blood/*metabolism [MESH] |Animals [MESH] |Blood Platelets/drug effects/*metabolism [MESH] |Disease Models, Animal [MESH] |Endothelial Cells/metabolism [MESH] |Fibrosis [MESH] |Gene Expression [MESH] |Hypertension/chemically induced/complications [MESH] |Immunohistochemistry [MESH] |Male [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Myocarditis/diagnosis/*etiology/*metabolism [MESH] |Myocardium/metabolism/pathology [MESH]P?selectin increases angiotensin II?induced cardiac inflammation and f(epmc).pdf DeepDyve Pubget Overpricing