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2016 ; 113
(20
): 5652-7
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A genetic method for dating ancient genomes provides a direct estimate of human
generation interval in the last 45,000 years
#MMPMID27140627
Moorjani P
; Sankararaman S
; Fu Q
; Przeworski M
; Patterson N
; Reich D
Proc Natl Acad Sci U S A
2016[May]; 113
(20
): 5652-7
PMID27140627
show ga
The study of human evolution has been revolutionized by inferences from ancient
DNA analyses. Key to these studies is the reliable estimation of the age of
ancient specimens. High-resolution age estimates can often be obtained using
radiocarbon dating, and, while precise and powerful, this method has some biases,
making it of interest to directly use genetic data to infer a date for samples
that have been sequenced. Here, we report a genetic method that uses the
recombination clock. The idea is that an ancient genome has evolved less than the
genomes of present-day individuals and thus has experienced fewer recombination
events since the common ancestor. To implement this idea, we take advantage of
the insight that all non-Africans have a common heritage of Neanderthal gene flow
into their ancestors. Thus, we can estimate the date since Neanderthal admixture
for present-day and ancient samples simultaneously and use the difference as a
direct estimate of the ancient specimen's age. We apply our method to date five
Upper Paleolithic Eurasian genomes with radiocarbon dates between 12,000 and
45,000 y ago and show an excellent correlation of the genetic and (14)C dates. By
considering the slope of the correlation between the genetic dates, which are in
units of generations, and the (14)C dates, which are in units of years, we infer
that the mean generation interval in humans over this period has been 26-30 y.
Extensions of this methodology that use older shared events may be applicable for
dating beyond the radiocarbon frontier.
free
free
free
