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10.1073/pnas.1524267113 http://scihub22266oqcxt.onion/10.1073/pnas.1524267113 C4878465!4878465 !27140614     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27140614 &cmd=llinks): Failed to open stream: HTTP request failed! 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Peptidoglycan-linked protein A promotes T cell-dependent antibody expansion during Staphylococcus aureus infection |pdf=|usr=}}{{27140614 }} gab.com Text Peptidoglycan-linked protein A promotes T cell-dependent antibody expansion during Staphylococcus aureus infection JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27140614 #FOAvip A hallmark of Staphylococcus aureus disease in humans is persistent infections without development of protective immune responses. Infected patients generate VH3 plasmablast expansions and increased VH3 idiotype Ig; however, the mechanisms for staphylococcal modification of immune responses are not known. We report here that S. aureus-infected mice generate VH3 antibody expansions via a mechanism requiring MHC-restricted antigen presentation to CD4(+) T cells and staphylococcal protein A (SpA), a cell wall-anchored surface molecule that binds Fc? and VH3 variant heavy chains of Ig. VH3 expansion occurred with peptidoglycan-linked SpA from the bacterial envelope but not with recombinant SpA, and optimally required five tandem repeats of its Ig-binding domains. Signaling via receptor-interacting serine/threonine protein kinase 2 (RIPK2) was essential for implementing peptidoglycan-linked SpA superantigen activity. VH3 clan IgG from S. aureus-infected or SpA-treated animals was not pathogen-specific, suggesting that SpA cross-linking of VH3 idiotype B-cell receptors and activation via attached peptidoglycan are the determinants of staphylococcal escape from adaptive immune responses. Twit Text FOAVip Peptidoglycan-linked protein A promotes T cell-dependent antibody expansion during Staphylococcus aureus infection ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27140614 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27140614 #FOAvip English Wikipedia <ref>{{Cite pmid|27140614 }}</ref> Peptidoglycan-linked protein A promotes T cell-dependent antibody expansion during Staphylococcus aureus infection #MMPMID27140614 Kim HK ; Falugi F ; Missiakas DM ; Schneewind O Proc Natl Acad Sci U S A 2016[May]; 113 (20 ): 5718-23 PMID27140614 show ga A hallmark of Staphylococcus aureus disease in humans is persistent infections without development of protective immune responses. Infected patients generate VH3 plasmablast expansions and increased VH3 idiotype Ig; however, the mechanisms for staphylococcal modification of immune responses are not known. We report here that S. aureus-infected mice generate VH3 antibody expansions via a mechanism requiring MHC-restricted antigen presentation to CD4(+) T cells and staphylococcal protein A (SpA), a cell wall-anchored surface molecule that binds Fc? and VH3 variant heavy chains of Ig. VH3 expansion occurred with peptidoglycan-linked SpA from the bacterial envelope but not with recombinant SpA, and optimally required five tandem repeats of its Ig-binding domains. Signaling via receptor-interacting serine/threonine protein kinase 2 (RIPK2) was essential for implementing peptidoglycan-linked SpA superantigen activity. VH3 clan IgG from S. aureus-infected or SpA-treated animals was not pathogen-specific, suggesting that SpA cross-linking of VH3 idiotype B-cell receptors and activation via attached peptidoglycan are the determinants of staphylococcal escape from adaptive immune responses. |Animals [MESH] |Antibodies, Bacterial/*biosynthesis/blood [MESH] |Antibody Formation [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred C57BL [MESH] |Peptidoglycan/immunology [MESH] |Staphylococcal Infections/blood/*immunology/microbiology [MESH] |Staphylococcal Protein A/*immunology [MESH] |Staphylococcus aureus/*immunology [MESH]Peptidoglycan-linked protein A promotes T cell-dependent antibody expa(epmc).pdf DeepDyve Pubget Overpricing