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10.1038/nature17040

http://scihub22266oqcxt.onion/10.1038/nature17040
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C4878406!4878406!26791722
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suck abstract from ncbi

pmid26791722      Nature 2016 ; 529 (7586): 316-25
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  • Angiocrine functions of organ-specific endothelial cells #MMPMID26791722
  • Rafii S; Butler JM; Ding BS
  • Nature 2016[Jan]; 529 (7586): 316-25 PMID26791722show ga
  • Endothelial cells lining blood vessel capillaries are not just passive conduits for delivering blood. Tissue-specific endothelium establish specialized vascular niches that deploy specific sets of growth factors, known as angiocrine factors, which actively participate in inducing, specifying, patterning, and guiding organ regeneration and maintaining homeostasis and metabolism. Angiocrine factors upregulated in response to injury orchestrates self-renewal and differentiation of tissue-specific repopulating resident stem and progenitor cells into functional organs. Uncovering the precise mechanisms whereby physiological-levels of angiocrine factors are spatially and temporally produced, and distributed by organotypic endothelium to repopulating cells, will lay the foundation for driving organ repair without scarring.
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