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10.1194/jlr.M064089 http://scihub22266oqcxt.onion/10.1194/jlr.M064089 C4878183!4878183 !27044658     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27044658 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Lipid+Res 2016 ; 57 (6 ): 980-92 Nephropedia Template TP {{tp|p=27044658 |t=2016. Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation |pdf=|usr=}}{{27044658 }} gab.com Text Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation JO: J Lipid Res http://www.kidney.de/pget.php?&tw=1&pmid=27044658 #FOAvip Many types of apoptotic cells are phagocytosed and digested by macrophages. Adipocytes can be hundreds of times larger than macrophages, so they are too large to be digested by conventional phagocytic processes. The nature of the interaction between macrophages and apoptotic adipocytes has not been studied in detail. We describe a cellular process, termed exophagy, that is important for macrophage clearance of dead adipocytes and adipose tissue homeostasis. Using mouse models of obesity, human tissue, and a cell culture model, we show that macrophages form hydrolytic extracellular compartments at points of contact with dead adipocytes using local actin polymerization. These compartments are acidic and contain lysosomal enzymes delivered by exocytosis. Uptake and complete degradation of adipocyte fragments, which are released by extracellular hydrolysis, leads to macrophage foam cell formation. Exophagy-mediated foam cell formation is a highly efficient means by which macrophages internalize large amounts of lipid, which may ultimately overwhelm the metabolic capacity of the macrophage. This process provides a mechanism for degradation of objects, such as dead adipocytes, that are too large to be phagocytosed by macrophages. Twit Text FOAVip Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation ????J Lipid Res http://www.kidney.de/pget.php?&tw=1&pmid=27044658 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27044658 #FOAvip English Wikipedia <ref>{{Cite pmid|27044658 }}</ref> Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation #MMPMID27044658 Haka AS ; Barbosa-Lorenzi VC ; Lee HJ ; Falcone DJ ; Hudis CA ; Dannenberg AJ ; Maxfield FR J Lipid Res 2016[Jun]; 57 (6 ): 980-92 PMID27044658 show ga Many types of apoptotic cells are phagocytosed and digested by macrophages. Adipocytes can be hundreds of times larger than macrophages, so they are too large to be digested by conventional phagocytic processes. The nature of the interaction between macrophages and apoptotic adipocytes has not been studied in detail. We describe a cellular process, termed exophagy, that is important for macrophage clearance of dead adipocytes and adipose tissue homeostasis. Using mouse models of obesity, human tissue, and a cell culture model, we show that macrophages form hydrolytic extracellular compartments at points of contact with dead adipocytes using local actin polymerization. These compartments are acidic and contain lysosomal enzymes delivered by exocytosis. Uptake and complete degradation of adipocyte fragments, which are released by extracellular hydrolysis, leads to macrophage foam cell formation. Exophagy-mediated foam cell formation is a highly efficient means by which macrophages internalize large amounts of lipid, which may ultimately overwhelm the metabolic capacity of the macrophage. This process provides a mechanism for degradation of objects, such as dead adipocytes, that are too large to be phagocytosed by macrophages. |Adipocytes/*physiology [MESH] |Adipose Tissue/metabolism/physiology [MESH] |Animals [MESH] |Exocytosis/*physiology [MESH] |Foam Cells/pathology/physiology [MESH] |Humans [MESH] |Lysosomes/physiology [MESH] |Macrophages/metabolism/*physiology [MESH] |Mice [MESH] |Obesity/metabolism/*physiopathology [MESH]Exocytosis of macrophage lysosomes leads to digestion of apoptotic adi(epmc).pdf DeepDyve Pubget Overpricing