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2015 ; 3
(2
): 315-21
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Sleep Deficiency is a Modifiable Risk Factor for Obesity and Cognitive Impairment
and Associated with Elevated Visfatin
#MMPMID27275243
Kazem YM
; Shebini SM
; Moaty MI
; Fouad S
; Tapozada ST
Open Access Maced J Med Sci
2015[Jun]; 3
(2
): 315-21
PMID27275243
show ga
AIM: To study the interaction between sleep deprivation, obesity and cognitive
functions, and the effect of following a balanced low caloric diet and increasing
sleep duration on those variables. SUBJECTS AND METHODS: Ninety two obese females
with mean age 47.00 ± 2.00 years and body mass index (BMI) 36.14 ± 3.00 kg/m²
were divided into 3 groups according to their sleeping hours. They followed
balanced low-caloric diet and were instructed to increase sleeping hours. Full
clinical examination, 24 hours dietary intake recall, anthropometric
measurements, mini mental state test, questionnaire for subjective sleep and life
style evaluation were performed at baseline and after 2 months. Serum visfatin,
fasting blood glucose and C-peptide were assessed; Modified homeostatic model
assessment of insulin resistance was calculated. RESULTS: About one third of our
sample slept less than 6 hours daily, group (1), all patients had elevated
visfatin serum level (33.87 ± 2.8 ng/ml) with the highest level in group (1). At
base line, group (1) showed the highest BMI, lowest cognitive functions, highest
visfatin level and highest insulin resistance (P < 0.05). After 2 months of
intervention, improvement was recorded in all variables, with the best
improvement in group (1) after extending sleep duration (P < 0.05). CONCLUSION:
Sleep deprivation may be a modifiable risk factor for obesity, cognitive
impairment and visfatin elevation.