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2016 ; 14
(1
): 151
Nephropedia Template TP
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Contemporary management of fibrolamellar hepatocellular carcinoma: diagnosis,
treatment, outcome, prognostic factors, and recent developments
#MMPMID27215576
Kassahun WT
World J Surg Oncol
2016[May]; 14
(1
): 151
PMID27215576
show ga
Fibrolamellar hepatocellular carcinoma (FL-HCC) is a malignant liver tumor which
is thought to be a variant of conventional hepatocellular carcinoma (HCC). It
accounts for a small proportion of HCC cases and occurs in a distinctly different
group of patients which are young and usually not in the setting of chronic liver
disease. The diagnosis of FL-HCC requires the integration of clinical
information, imaging studies, and histology. In terms of the treatment options,
the only potentially curative treatment option for patients who have resectable
disease is surgery either liver resection (LR) or liver transplantation (LT).
When performed in a context of aggressive therapy, long-term outcomes after
surgery, particularly liver resection for FL-HCC, were favorable. The clinical
outcome of patients with unresectable disease is suboptimal with median survival
of less than 12 months. The aim of this review is to update the available
evidence on diagnosis, treatment options, outcome predictors, and recent
developments of patients with this rare disease and to provide a summarized
overview of the available literature.