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10.1186/s12890-016-0249-6 http://scihub22266oqcxt.onion/10.1186/s12890-016-0249-6 C4877734!4877734!27215343     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27215343&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Pulm+Med 2016 ; 16 (ä): ä Nephropedia Template TP {{tp|p=27215343|t=2016. Raised serum levels of IGFBP-1 and IGFBP-2 in idiopathic pulmonary fibrosis |pdf=|usr=}}{{27215343}} gab.com Text Raised serum levels of IGFBP-1 and IGFBP-2 in idiopathic pulmonary fibrosis JO: BMC Pulm Med http://www.kidney.de/pget.php?&tw=1&pmid=27215343 #FOAvip Background: Idiopathic pulmonary fibrosis (IPF) is a chronic lung disorder of unknown origin, which ultimately leads to death. Several growth factors such as IGFs (insulin-like-growth factor) and IGFBPs (insulin like growth factor binding proteins) seem to take part to the pathogenesis. We evaluated IGFs and IGFBPs in serum from patients with IPF and healthy subjects including 24 untreated IPF and 26 IPF receiving anti-fibrotic therapy and to compare them with healthy subjects. Methods: Serum of 50 idiopathic pulmonary fibrosis and 55 healthy subjects (HS) were analysed by ELISA for IGFs and IGFBPs, TGF-? and KL-6, the latter being tested as positive control in IPF. Results: Serum levels of IGFBP-1 and IGFBP-2 and KL-6 were significantly higher in the IPF group than in the healthy subjects (p?<?0.05, p?<?0.001 and p?<?0.0001 respectively) while the picture was inversed regarding IGFs. By contrast there was no significant difference between the groups with respect to TGF-?. IGFBP-2 was significantly reduced in the patients with specific anti-fibrotic therapy pirfenidone and nintedanib compared to untreated patients (p?<?0.05) but still significantly elevated in comparison to HS (p?<?0.001). Conclusion: Serum IGFBP-1 and ?2 are increased in idiopathic pulmonary fibrosis and IGFBP-2 may be reduced by anti-fibrosing therapy. IGFBPs may be promising biomarkers in IPF. Electronic supplementary material: The online version of this article (doi:10.1186/s12890-016-0249-6) contains supplementary material, which is available to authorized users. Twit Text FOAVip Raised serum levels of IGFBP-1 and IGFBP-2 in idiopathic pulmonary fibrosis ????BMC Pulm Med http://www.kidney.de/pget.php?&tw=1&pmid=27215343 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27215343 #FOAvip English Wikipedia <ref>{{Cite pmid|27215343}}</ref> Raised serum levels of IGFBP-1 and IGFBP-2 in idiopathic pulmonary fibrosis #MMPMID27215343 Guiot J; Bondue B; Henket M; Corhay JL; Louis R BMC Pulm Med 2016[]; 16 (ä): ä PMID27215343show ga Background: Idiopathic pulmonary fibrosis (IPF) is a chronic lung disorder of unknown origin, which ultimately leads to death. Several growth factors such as IGFs (insulin-like-growth factor) and IGFBPs (insulin like growth factor binding proteins) seem to take part to the pathogenesis. We evaluated IGFs and IGFBPs in serum from patients with IPF and healthy subjects including 24 untreated IPF and 26 IPF receiving anti-fibrotic therapy and to compare them with healthy subjects. Methods: Serum of 50 idiopathic pulmonary fibrosis and 55 healthy subjects (HS) were analysed by ELISA for IGFs and IGFBPs, TGF-? and KL-6, the latter being tested as positive control in IPF. Results: Serum levels of IGFBP-1 and IGFBP-2 and KL-6 were significantly higher in the IPF group than in the healthy subjects (p? äRaised serum levels of IGFBP-1 and IGFBP-2 in idiopathic pulmonary fib(epmc).pdf DeepDyve Pubget Overpricing