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10.1038/srep26274 http://scihub22266oqcxt.onion/10.1038/srep26274 C4877647!4877647 !27215188     free     free     free Deprecated: Implicit conversion from float 223.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 223.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 223.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 223.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 223.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 223.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 223.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 257.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 257.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 257.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27215188 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 26274 Nephropedia Template TP {{tp|p=27215188 |t=2016. Soluble CD59 is a Novel Biomarker for the Prediction of Obstructive Chronic Lung Allograft Dysfunction After Lung Transplantation |pdf=|usr=}}{{27215188 }} gab.com Text Soluble CD59 is a Novel Biomarker for the Prediction of Obstructive Chronic Lung Allograft Dysfunction After Lung Transplantation JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27215188 #FOAvip CD59 is a complement regulatory protein that inhibits membrane attack complex formation. A soluble form of CD59 (sCD59) is present in various body fluids and is associated with cellular damage after acute myocardial infarction. Lung transplantation (LTx) is the final treatment for end-stage lung diseases, however overall survival is hampered by chronic lung allograft dysfunction development, which presents itself obstructively as the bronchiolitis obliterans syndrome (BOS). We hypothesized that, due to cellular damage and activation during chronic inflammation, sCD59 serum levels can be used as biomarker preceding BOS development. We analyzed sCD59 serum concentrations in 90 LTx patients, of whom 20 developed BOS. We observed that BOS patients exhibited higher sCD59 serum concentrations at the time of diagnosis compared to clinically matched non-BOS patients (p?=?0.018). Furthermore, sCD59 titers were elevated at 6 months post-LTx (p?=?0.0020), when patients had no BOS-related symptoms. Survival-analysis showed that LTx patients with sCD59 titers ?400?pg/ml 6 months post-LTx have a significant (p?<?0.0001) lower chance of BOS-free survival than patients with titers ?400?pg/ml, 32% vs. 80% respectively, which was confirmed by multivariate analysis (hazard ratio 6.2, p?<?0.0001). We propose that circulating sCD59 levels constitute a novel biomarker to identify patients at risk for BOS following LTx. Twit Text FOAVip Soluble CD59 is a Novel Biomarker for the Prediction of Obstructive Chronic Lung Allograft Dysfunction After Lung Transplantation ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27215188 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27215188 #FOAvip English Wikipedia <ref>{{Cite pmid|27215188 }}</ref> Soluble CD59 is a Novel Biomarker for the Prediction of Obstructive Chronic Lung Allograft Dysfunction After Lung Transplantation #MMPMID27215188 Budding K ; van de Graaf EA ; Kardol-Hoefnagel T ; Kwakkel-van Erp JM ; Luijk BD ; Oudijk ED ; van Kessel DA ; Grutters JC ; Hack CE ; Otten HG Sci Rep 2016[May]; 6 (ä): 26274 PMID27215188 show ga CD59 is a complement regulatory protein that inhibits membrane attack complex formation. A soluble form of CD59 (sCD59) is present in various body fluids and is associated with cellular damage after acute myocardial infarction. Lung transplantation (LTx) is the final treatment for end-stage lung diseases, however overall survival is hampered by chronic lung allograft dysfunction development, which presents itself obstructively as the bronchiolitis obliterans syndrome (BOS). We hypothesized that, due to cellular damage and activation during chronic inflammation, sCD59 serum levels can be used as biomarker preceding BOS development. We analyzed sCD59 serum concentrations in 90 LTx patients, of whom 20 developed BOS. We observed that BOS patients exhibited higher sCD59 serum concentrations at the time of diagnosis compared to clinically matched non-BOS patients (p?=?0.018). Furthermore, sCD59 titers were elevated at 6 months post-LTx (p?=?0.0020), when patients had no BOS-related symptoms. Survival-analysis showed that LTx patients with sCD59 titers ?400?pg/ml 6 months post-LTx have a significant (p? |Adolescent [MESH] |Adult [MESH] |Allografts [MESH] |Biomarkers/blood [MESH] |Bronchiolitis Obliterans/*blood/*etiology/immunology [MESH] |CD59 Antigens/*blood [MESH] |Female [MESH] |Graft Rejection/blood/etiology/immunology [MESH] |Humans [MESH] |Kaplan-Meier Estimate [MESH] |Lung Transplantation/*adverse effects [MESH] |Male [MESH] |Middle Aged [MESH] |Multivariate Analysis [MESH] |Risk Factors [MESH] |Solubility [MESH] |Time Factors [MESH]Soluble CD59 is a Novel Biomarker for the Prediction of Obstructive Ch(epmc).pdf DeepDyve Pubget Overpricing