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10.1155/2016/5126560 http://scihub22266oqcxt.onion/10.1155/2016/5126560 C4877496!4877496 !27247798     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27247798 &cmd=llinks): Failed to open stream: HTTP request failed! 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Expression of Wnt/?-Catenin Signaling Pathway and Its Regulatory Role in Type I Collagen with TGF-?1 in Scleral Fibroblasts from an Experimentally Induced Myopia Guinea Pig Model |pdf=|usr=}}{{27247798 }} gab.com Text Expression of Wnt/ -Catenin Signaling Pathway and Its Regulatory Role in Type I Collagen with TGF- 1 in Scleral Fibroblasts from an Experimentally Induced Myopia Guinea Pig Model JO: J Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=27247798 #FOAvip Background. To investigate Wnt/?-catenin signaling pathway expression and its regulation of type I collagen by TGF-?1 in scleral fibroblasts from form-deprivation myopia (FDM) guinea pig model. Methods. Wnt isoforms were examined using genome microarrays. Scleral fibroblasts from FDM group and self-control (SC) group were cultured. Wnt isoforms, ?-catenin, TGF-?1, and type I collagen expression levels were examined in the two groups with or without DKK-1 or TGF-?1 neutralizing antibody. Results. For genome microarrays, the expression of Wnt3 in FDM group was significantly greater as confirmed in retinal and scleral tissue. The expression of Wnt3 and ?-catenin significantly increased in FDM group and decreased significantly with DKK-1. TGF-?1 expression level decreased significantly in FDM group and increased significantly with DKK-1. Along with morphological misalignment inside and outside cells, the amount of type I collagen decreased in FDM group. Furthermore, type I collagen increased and became regular in DKK-1 intervention group, whereas it decreased and rearranged more disorder in TGF-?1 neutralizing antibody intervention group. Conclusions. The activation of Wnt3/?-catenin signaling pathway was demonstrated in primary scleral fibroblasts in FDM. This pathway further reduced the expression of type I collagen by TGF-?1, which ultimately played a role in scleral remodeling during myopia development. Twit Text FOAVip Expression of Wnt/ -Catenin Signaling Pathway and Its Regulatory Role in Type I Collagen with TGF- 1 in Scleral Fibroblasts from an Experimentally Induced Myopia Guinea Pig Model ????J Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=27247798 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27247798 #FOAvip English Wikipedia <ref>{{Cite pmid|27247798 }}</ref> Expression of Wnt/?-Catenin Signaling Pathway and Its Regulatory Role in Type I Collagen with TGF-?1 in Scleral Fibroblasts from an Experimentally Induced Myopia Guinea Pig Model #MMPMID27247798 Li M ; Yuan Y ; Chen Q ; Me R ; Gu Q ; Yu Y ; Sheng M ; Ke B J Ophthalmol 2016[]; 2016 (ä): 5126560 PMID27247798 show ga Background. To investigate Wnt/?-catenin signaling pathway expression and its regulation of type I collagen by TGF-?1 in scleral fibroblasts from form-deprivation myopia (FDM) guinea pig model. Methods. Wnt isoforms were examined using genome microarrays. Scleral fibroblasts from FDM group and self-control (SC) group were cultured. Wnt isoforms, ?-catenin, TGF-?1, and type I collagen expression levels were examined in the two groups with or without DKK-1 or TGF-?1 neutralizing antibody. Results. For genome microarrays, the expression of Wnt3 in FDM group was significantly greater as confirmed in retinal and scleral tissue. The expression of Wnt3 and ?-catenin significantly increased in FDM group and decreased significantly with DKK-1. TGF-?1 expression level decreased significantly in FDM group and increased significantly with DKK-1. Along with morphological misalignment inside and outside cells, the amount of type I collagen decreased in FDM group. Furthermore, type I collagen increased and became regular in DKK-1 intervention group, whereas it decreased and rearranged more disorder in TGF-?1 neutralizing antibody intervention group. Conclusions. The activation of Wnt3/?-catenin signaling pathway was demonstrated in primary scleral fibroblasts in FDM. This pathway further reduced the expression of type I collagen by TGF-?1, which ultimately played a role in scleral remodeling during myopia development. äExpression of Wnt/?-Catenin Signaling Pathway and Its Regulatory Role (epmc).pdf DeepDyve Pubget Overpricing