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2016 ; 8
(ä): 61-8
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Paritaprevir/ritonavir-ombitasvir and dasabuvir, the 3D regimen for the treatment
of chronic hepatitis C virus infection: a concise review
#MMPMID27274322
Hussaini T
Hepat Med
2016[]; 8
(ä): 61-8
PMID27274322
show ga
The treatment for chronic hepatitis C has been revolutionized with the
development of direct-acting antiviral agents. Several regimens have been
approved and are currently used in clinical practice, treating a wide range of
patient populations infected with hepatitis C. The interferon-free combination of
paritaprevir/ritonavir-ombitasvir and dasabuvir (PrOD or the three-drug [3D]
regimen) with or without ribavirin is indicated for the treatment of chronic
hepatitis C in both treatment-naïve and experienced patients infected with
genotype 1, including those coinfected with HIV and patients post-liver
transplantation. More recently, paritaprevir/ritonavir-ombitasvir (PrO, or 2D
regimen) has been approved in hepatitis C virus patients infected with genotype
4. This review will summarize pharmacokinetic and clinical efficacy data for the
3D regimen in an attempt to help the clinicians delineate its place in the
ever-increasing direct-acting antiviral armamentarium for the treatment of
chronic hepatitis C.