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2016 ; 11
(ä): 1053-9
Nephropedia Template TP
gab.com Text
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English Wikipedia
Hyperlipidemia in COPD is associated with decreased incidence of pneumonia and
mortality: a nationwide health insurance data-based retrospective cohort study
#MMPMID27274227
Chan MC
; Lin CH
; Kou YR
Int J Chron Obstruct Pulmon Dis
2016[]; 11
(ä): 1053-9
PMID27274227
show ga
PURPOSE: COPD is often associated with various comorbidities that may influence
its outcomes. Pneumonia, cardiovascular disease (CVD), and cancer are the major
causes of death in COPD patients. The objective of this study is to investigate
the influence of comorbidities on COPD by using the Taiwan National Health
Insurance database. PATIENTS AND METHODS: We retrospectively analyzed the
database in 2006 of one million sampling cohort. Newly diagnosed patients with
COPD with a controlled cohort that was matched by age, sex, and Charlson
comorbidity index (CCI) were included for analysis. RESULTS: In total, 1,491
patients with COPD were included for analysis (61.8% male). Patients with COPD
had higher incidences of pneumonia (25.7% vs 10.4%; P<0.0001), CVD (15.1% vs
10.5%; P<0.0001), and mortality rate (26.6% vs 15.8%; P<0.001) compared with the
control group in the 4-year follow-up. In patients with COPD, CCI ?3 have a
higher incidence of pneumonia (hazard ratio [HR] 1.61; 95% confidence interval
[CI] 1.23-2.09; P<0.0001), CVD (HR 1.73; 95% CI 1.24-2.41; P=0.001), and
mortality (HR 1.12; 95% CI 1.12-1.83; P=0.004). Among the major comorbidities of
COPD, hyperlipidemia was associated with decreased incidence of pneumonia (HR
0.68; 95% CI 0.5-0.93; P=0.016) and mortality (HR 0.64; 95% CI 0.46-0.90;
P=0.009), but was not associated with increased risk of CVD (HR 1.10; 95% CI
0.78-1.55; P=0.588). CONCLUSION: Our results demonstrate that COPD is associated
with increased incidence of pneumonia, CVD, and mortality. In patients with COPD,
higher CCI is associated with increased incidence of pneumonia, CVD, and
mortality. However, COPD with hyperlipidemia is associated with decreased
incidence of pneumonia and mortality.