FCRL6 is an MHC class II receptor1 #MMPMID20519654
Schreeder DM; Cannon JP; Wu J; Li R; Shakhmatov MA; Davis RS
J Immunol 2010[Jul]; 185 (1): 23-7 PMID20519654show ga
Receptors for the Fc portion (FCR) of Ig have been extensively characterized and are known to regulate humoral responses, but members of the closely related FCR-like (FCRL) family have not been found to bind Ig and to date no ligand has been identified for any FCRL. Using a cell-based GFP reporter system and a recombinant Fc chimeric protein, we show that human FCRL6, a receptor selectively expressed by cytotoxic T and NK cells, directly binds HLA-DR, a major histocompatibility complex (MHC) class II molecule. Given the similarity among constant regions of Ig and MHC molecules, these findings suggest that representatives of the FCR and FCRL multigene families may have independently evolved to engage two ancestral elements fundamental to adaptive immunity. This discovery may offer new insight into the interaction between cytotoxic lymphocytes and antigen presenting cells and may have important implications for better understanding HLA disease susceptibility and pathogenesis.
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J+Immunol 2010 ; 185 (1): 23-7
