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10.2147/CIA.S105769 http://scihub22266oqcxt.onion/10.2147/CIA.S105769 C4876682!4876682!27274215     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Interv+Aging 2016 ; 11 (ä): 665-81 Nephropedia Template TP {{tp|p=27274215|t=2016. Genes associated with Alzheimer?s disease: an overview and current status |pdf=|usr=}}{{27274215}} gab.com Text Genes associated with Alzheimer s disease: an overview and current status JO: Clin Interv Aging http://www.kidney.de/pget.php?&tw=1&pmid=27274215 #FOAvip Alzheimer?s disease (AD) is a progressive, neurodegenerative disease and the most common form of dementia in elderly people. It is an emerging public health problem that poses a huge societal burden. Linkage analysis was the first milestone in unraveling the mutations in APP, PSEN1, and PSEN2 that cause early-onset AD, followed by the discovery of apolipoprotein E-?4 allele as the only one genetic risk factor for late-onset AD. Genome-wide association studies have revolutionized genetic research and have identified over 20 genetic loci associated with late-onset AD. Recently, next-generation sequencing technologies have enabled the identification of rare disease variants, including unmasking small mutations with intermediate risk of AD in PLD3, TREM2, UNC5C, AKAP9, and ADAM10. This review provides an overview of the genetic basis of AD and the relationship between these risk genes and the neuropathologic features of AD. An understanding of genetic mechanisms underlying AD pathogenesis and the potentially implicated pathways will lead to the development of novel treatment for this devastating disease. Twit Text FOAVip Genes associated with Alzheimer s disease: an overview and current status ????Clin Interv Aging http://www.kidney.de/pget.php?&tw=1&pmid=27274215 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27274215 #FOAvip English Wikipedia <ref>{{Cite pmid|27274215}}</ref> Genes associated with Alzheimer?s disease: an overview and current status #MMPMID27274215 Giri M; Zhang M; Lü Y Clin Interv Aging 2016[]; 11 (ä): 665-81 PMID27274215show ga Alzheimer?s disease (AD) is a progressive, neurodegenerative disease and the most common form of dementia in elderly people. It is an emerging public health problem that poses a huge societal burden. Linkage analysis was the first milestone in unraveling the mutations in APP, PSEN1, and PSEN2 that cause early-onset AD, followed by the discovery of apolipoprotein E-?4 allele as the only one genetic risk factor for late-onset AD. Genome-wide association studies have revolutionized genetic research and have identified over 20 genetic loci associated with late-onset AD. Recently, next-generation sequencing technologies have enabled the identification of rare disease variants, including unmasking small mutations with intermediate risk of AD in PLD3, TREM2, UNC5C, AKAP9, and ADAM10. This review provides an overview of the genetic basis of AD and the relationship between these risk genes and the neuropathologic features of AD. An understanding of genetic mechanisms underlying AD pathogenesis and the potentially implicated pathways will lead to the development of novel treatment for this devastating disease. äGenes associated with Alzheimer?s disease: an overview and current sta(epmc).pdf DeepDyve Pubget Overpricing