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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Crit+Rev+Biotechnol 2015 ; 35 (2): 235-54 Nephropedia Template TP
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Fc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeutics #MMPMID24156398
Crit Rev Biotechnol 2015[Jun]; 35 (2): 235-54 PMID24156398show ga
Nearly 350 IgG-based therapeutics are approved for clinical use or are under development for many diseases lacking adequate treatment options. These include molecularly engineered biologicals comprising the IgG Fc-domain fused to various effector molecules (so-called Fc-fusion proteins) that confer the advantages of IgG, including binding to the neonatal Fc receptor (FcRn) to facilitate in vivo stability, and the therapeutic benefit of the specific effector functions. Advances in IgG structure-function relationships and an understanding of FcRn biology have provided therapeutic opportunities for previously unapproachable diseases. This article discusses approved Fc-fusion therapeutics, novel Fc-fusion proteins and FcRn-dependent delivery approaches in development, and how engineering of the FcRn?Fc interaction can generate longer-lasting and more effective therapeutics.