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10.1101/sqb.2011.76.010942 http://scihub22266oqcxt.onion/10.1101/sqb.2011.76.010942 C4876600!4876600!22096030     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cold+Spring+Harb+Symp+Quant+Biol 2011 ; 76 (ä): 285-9 Nephropedia Template TP {{tp|p=22096030|t=2011. Regulation of Glycolysis and Gluconeogenesis by Acetylation of PKM and PEPCK |pdf=|usr=}}{{22096030}} gab.com Text Regulation of Glycolysis and Gluconeogenesis by Acetylation of PKM and PEPCK JO: Cold Spring Harb Symp Quant Biol http://www.kidney.de/pget.php?&tw=1&pmid=22096030 #FOAvip Glycolysis is a catabolic process of glucose hydrolysis needed for energy and biosynthetic intermediates, whereas gluconeogenesis is a glucose production process important for maintaining blood glucose levels during starvation. Although they share many enzymes, these two processes are not simply the reverse of each other and are instead reciprocally regulated. Two key enzymes that regulate irreversible steps in these two processes are pyruvate kinase (PK) and phosphoenolpyruvate carboxy kinase (PEPCK), which catalyze the last and first step of glycolysis and gluconeogenesis, respectively, and are both regulated by lysine acetylation. Acetylation at Lys305 of the PKM (muscle form of PK) decreases its activity and also targets it for chaperone-mediated autophagy and subsequent lysosome degradation. Acetylation of PEPCK, on the other hand, targets it for ubiquitylation by the HECT E3 ligase, UBR5/EDD1, and subsequent proteasomal degradation. These studies established a model in which acetylation regulates metabolic enzymes via different mechanisms and also revealed cross talk between acetylation and ubiquitination. Given that most metabolic enzymes are acetylated, we propose that acetylation is a major posttranslational modifier that regulates cellular metabolism. Twit Text FOAVip Regulation of Glycolysis and Gluconeogenesis by Acetylation of PKM and PEPCK ????Cold Spring Harb Symp Quant Biol http://www.kidney.de/pget.php?&tw=1&pmid=22096030 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22096030 #FOAvip English Wikipedia <ref>{{Cite pmid|22096030}}</ref> Regulation of Glycolysis and Gluconeogenesis by Acetylation of PKM and PEPCK #MMPMID22096030 Xiong Y; Lei QY; Zhao S; Guan KL Cold Spring Harb Symp Quant Biol 2011[]; 76 (ä): 285-9 PMID22096030show ga Glycolysis is a catabolic process of glucose hydrolysis needed for energy and biosynthetic intermediates, whereas gluconeogenesis is a glucose production process important for maintaining blood glucose levels during starvation. Although they share many enzymes, these two processes are not simply the reverse of each other and are instead reciprocally regulated. Two key enzymes that regulate irreversible steps in these two processes are pyruvate kinase (PK) and phosphoenolpyruvate carboxy kinase (PEPCK), which catalyze the last and first step of glycolysis and gluconeogenesis, respectively, and are both regulated by lysine acetylation. Acetylation at Lys305 of the PKM (muscle form of PK) decreases its activity and also targets it for chaperone-mediated autophagy and subsequent lysosome degradation. Acetylation of PEPCK, on the other hand, targets it for ubiquitylation by the HECT E3 ligase, UBR5/EDD1, and subsequent proteasomal degradation. These studies established a model in which acetylation regulates metabolic enzymes via different mechanisms and also revealed cross talk between acetylation and ubiquitination. Given that most metabolic enzymes are acetylated, we propose that acetylation is a major posttranslational modifier that regulates cellular metabolism. äRegulation of Glycolysis and Gluconeogenesis by Acetylation of PKM and(epmc).pdf DeepDyve Pubget Overpricing