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10.1038/srep26385 http://scihub22266oqcxt.onion/10.1038/srep26385 C4876444!4876444 !27210613     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27210613 &cmd=llinks): Failed to open stream: HTTP request failed! 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Two-Photon Enzymatic Probes Visualizing Sub-cellular/Deep-brain Caspase Activities in Neurodegenerative Models |pdf=|usr=}}{{27210613 }} gab.com Text Two-Photon Enzymatic Probes Visualizing Sub-cellular/Deep-brain Caspase Activities in Neurodegenerative Models JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27210613 #FOAvip Caspases work as a double-edged sword in maintaining cell homeostasis. Highly regulated caspase activities are essential during animal development, but dysregulation might lead to different diseases, e.g. extreme caspase activation is known to promote neurodegeneration. At present, visualization of caspase activation has mostly remained at the cellular level, in part due to a lack of cell-permeable imaging probes capable of direct, real-time investigations of endogenous caspase activities in deep tissues. Herein, we report a suite of two-photon, small molecule/peptide probes which enable sensitive and dynamic imaging of individual caspase activities in neurodegenerative models under physiological conditions. With no apparent toxicity and the ability of imaging endogenous caspases both in different subcellular organelles of mammalian cells and in brain tissues, these probes serve as complementary tools to conventional histological analysis. They should facilitate future explorations of caspases at molecular, cellular and organism levels and inspire development of novel two-photon probes against other enzymes. Twit Text FOAVip Two-Photon Enzymatic Probes Visualizing Sub-cellular/Deep-brain Caspase Activities in Neurodegenerative Models ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27210613 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27210613 #FOAvip English Wikipedia <ref>{{Cite pmid|27210613 }}</ref> Two-Photon Enzymatic Probes Visualizing Sub-cellular/Deep-brain Caspase Activities in Neurodegenerative Models #MMPMID27210613 Qian L ; Zhang CW ; Mao Y ; Li L ; Gao N ; Lim KL ; Xu QH ; Yao SQ Sci Rep 2016[May]; 6 (ä): 26385 PMID27210613 show ga Caspases work as a double-edged sword in maintaining cell homeostasis. Highly regulated caspase activities are essential during animal development, but dysregulation might lead to different diseases, e.g. extreme caspase activation is known to promote neurodegeneration. At present, visualization of caspase activation has mostly remained at the cellular level, in part due to a lack of cell-permeable imaging probes capable of direct, real-time investigations of endogenous caspase activities in deep tissues. Herein, we report a suite of two-photon, small molecule/peptide probes which enable sensitive and dynamic imaging of individual caspase activities in neurodegenerative models under physiological conditions. With no apparent toxicity and the ability of imaging endogenous caspases both in different subcellular organelles of mammalian cells and in brain tissues, these probes serve as complementary tools to conventional histological analysis. They should facilitate future explorations of caspases at molecular, cellular and organism levels and inspire development of novel two-photon probes against other enzymes. |Animals [MESH] |Brain/*enzymology [MESH] |Caspases/*chemistry/metabolism [MESH] |Cell Line [MESH] |HeLa Cells [MESH] |Humans [MESH] |Microscopy, Fluorescence, Multiphoton [MESH] |Models, Biological [MESH] |Molecular Probes/*chemistry [MESH]Two-Photon Enzymatic Probes Visualizing Sub-cellular/Deep-brain Caspas(epmc).pdf DeepDyve Pubget Overpricing