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10.1038/srep26563 http://scihub22266oqcxt.onion/10.1038/srep26563 C4876423!4876423 !27212152     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27212152 &cmd=llinks): Failed to open stream: HTTP request failed! 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Protamine zinc insulin combined with sodium selenite improves glycometabolism in the diabetic KKAy mice |pdf=|usr=}}{{27212152 }} gab.com Text Protamine zinc insulin combined with sodium selenite improves glycometabolism in the diabetic KKAy mice JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27212152 #FOAvip Long-term, high dosage protamine zinc insulin (PZI) treatments produce adverse reactions. The trace element selenium (Se) is a candidate for the prevention of diabetes due to anti-oxidative stress activity and the regulation of glycometabolism. In this study, we aimed to investigate the anti-diabetic effects of a combination of PZI and Se on type 2 diabetes. Diabetic KKAy mice were randomized into the following groups: model group and groups that were subcutaneously injected with PZI, Se, high or low dose PZI + Se for 6 weeks. PZI combined with Se decreased the body weight and fasting blood glucose levels. Moreover, this treatment also improved insulin tolerance, as determined by the reduced values from the oral glucose tolerance test and insulin tolerance test, and increased insulin levels and insulin sensitivity index. PZI combined with Se ameliorated skeletal muscle and ?-cell damage and the impaired mitochondrial morphology. Oxidative stress was also reduced. Furthermore, PZI combined with Se upregulated phosphatidylinositol 3-kinase (PI3K) and downregulated protein tyrosine phosphatase 1B (PTP1B). Importantly, the low dosage combination produced effects similar to PZI alone. In conclusion, PZI combined with Se improved glycometabolism and ameliorated the tissue and mitochondrial damage, which might be associated with the PI3K and PTP1B pathways. Twit Text FOAVip Protamine zinc insulin combined with sodium selenite improves glycometabolism in the diabetic KKAy mice ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27212152 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27212152 #FOAvip English Wikipedia <ref>{{Cite pmid|27212152 }}</ref> Protamine zinc insulin combined with sodium selenite improves glycometabolism in the diabetic KKAy mice #MMPMID27212152 Lu J ; Ji W ; Zhao M ; Wang M ; Yan W ; Chen M ; Ren S ; Yuan B ; Wang B ; Chen L Sci Rep 2016[May]; 6 (ä): 26563 PMID27212152 show ga Long-term, high dosage protamine zinc insulin (PZI) treatments produce adverse reactions. The trace element selenium (Se) is a candidate for the prevention of diabetes due to anti-oxidative stress activity and the regulation of glycometabolism. In this study, we aimed to investigate the anti-diabetic effects of a combination of PZI and Se on type 2 diabetes. Diabetic KKAy mice were randomized into the following groups: model group and groups that were subcutaneously injected with PZI, Se, high or low dose PZI + Se for 6 weeks. PZI combined with Se decreased the body weight and fasting blood glucose levels. Moreover, this treatment also improved insulin tolerance, as determined by the reduced values from the oral glucose tolerance test and insulin tolerance test, and increased insulin levels and insulin sensitivity index. PZI combined with Se ameliorated skeletal muscle and ?-cell damage and the impaired mitochondrial morphology. Oxidative stress was also reduced. Furthermore, PZI combined with Se upregulated phosphatidylinositol 3-kinase (PI3K) and downregulated protein tyrosine phosphatase 1B (PTP1B). Importantly, the low dosage combination produced effects similar to PZI alone. In conclusion, PZI combined with Se improved glycometabolism and ameliorated the tissue and mitochondrial damage, which might be associated with the PI3K and PTP1B pathways. |Animals [MESH] |Blood Glucose/*drug effects [MESH] |Body Weight/drug effects [MESH] |Diabetes Mellitus, Type 2/blood/*drug therapy/metabolism [MESH] |Drug Therapy, Combination [MESH] |Gene Expression Regulation/drug effects [MESH] |Glucose Tolerance Test [MESH] |Hypoglycemic Agents/*administration & dosage/pharmacology [MESH] |Insulin, Isophane/*administration & dosage/pharmacology [MESH] |Insulin-Secreting Cells/cytology/drug effects [MESH] |Insulin/blood [MESH] |Mice [MESH] |Mitochondria/drug effects [MESH] |Muscle Cells/cytology/drug effects [MESH] |Muscle, Skeletal/cytology/drug effects [MESH] |Oxidative Stress/drug effects [MESH] |Random Allocation [MESH]Protamine zinc insulin combined with sodium selenite improves glycomet(epmc).pdf DeepDyve Pubget Overpricing