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10.1038/srep26413 http://scihub22266oqcxt.onion/10.1038/srep26413 C4876403!4876403 !27212225     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27212225 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 26413 Nephropedia Template TP {{tp|p=27212225 |t=2016. Suppression of 14-3-3?-mediated surface expression of ANO1 inhibits cancer progression of glioblastoma cells |pdf=|usr=}}{{27212225 }} gab.com Text Suppression of 14-3-3 -mediated surface expression of ANO1 inhibits cancer progression of glioblastoma cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27212225 #FOAvip Anoctamin-1 (ANO1) acts as a Ca(2+)-activated Cl(-) channel in various normal tissues, and its expression is increased in several different types of cancer. Therefore, understanding the regulation of ANO1 surface expression is important for determining its physiological and pathophysiological functions. However, the trafficking mechanism of ANO1 remains elusive. Here, we report that segment a (N-terminal 116 amino acids) of ANO1 is crucial for its surface expression, and we identified 14-3-3? as a binding partner for anterograde trafficking using yeast two-hybrid screening. The surface expression of ANO1 was enhanced by 14-3-3?, and the Thr9 residue of ANO1 was critical for its interaction with 14-3-3?. Gene silencing of 14-3-3? and/or ANO1 demonstrated that suppression of ANO1 surface expression inhibited migration and invasion of glioblastoma cells. These findings provide novel therapeutic implications for glioblastomas, which are associated with poor prognosis. Twit Text FOAVip Suppression of 14-3-3 -mediated surface expression of ANO1 inhibits cancer progression of glioblastoma cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27212225 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27212225 #FOAvip English Wikipedia <ref>{{Cite pmid|27212225 }}</ref> Suppression of 14-3-3?-mediated surface expression of ANO1 inhibits cancer progression of glioblastoma cells #MMPMID27212225 Lee YS ; Lee JK ; Bae Y ; Lee BS ; Kim E ; Cho CH ; Ryoo K ; Yoo J ; Kim CH ; Yi GS ; Lee SG ; Lee CJ ; Kang SS ; Hwang EM ; Park JY Sci Rep 2016[May]; 6 (ä): 26413 PMID27212225 show ga Anoctamin-1 (ANO1) acts as a Ca(2+)-activated Cl(-) channel in various normal tissues, and its expression is increased in several different types of cancer. Therefore, understanding the regulation of ANO1 surface expression is important for determining its physiological and pathophysiological functions. However, the trafficking mechanism of ANO1 remains elusive. Here, we report that segment a (N-terminal 116 amino acids) of ANO1 is crucial for its surface expression, and we identified 14-3-3? as a binding partner for anterograde trafficking using yeast two-hybrid screening. The surface expression of ANO1 was enhanced by 14-3-3?, and the Thr9 residue of ANO1 was critical for its interaction with 14-3-3?. Gene silencing of 14-3-3? and/or ANO1 demonstrated that suppression of ANO1 surface expression inhibited migration and invasion of glioblastoma cells. These findings provide novel therapeutic implications for glioblastomas, which are associated with poor prognosis. |14-3-3 Proteins/*metabolism [MESH] |Anoctamin-1/*chemistry/*metabolism [MESH] |Binding Sites [MESH] |Brain Neoplasms/*metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Membrane/metabolism [MESH] |Cell Movement [MESH] |Disease Progression [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Glioblastoma/*metabolism [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Neoplasm Invasiveness [MESH] |Neoplasm Proteins/*chemistry/*metabolism [MESH] |Protein Binding [MESH]Suppression of 14-3-3?-mediated surface expression of ANO1 inhibits ca(epmc).pdf DeepDyve Pubget Overpricing