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10.1038/srep26554 http://scihub22266oqcxt.onion/10.1038/srep26554 C4876378!4876378 !27212040     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27212040 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 26554 Nephropedia Template TP {{tp|p=27212040 |t=2016. Honokiol suppresses TNF-?-induced neutrophil adhesion on cerebral endothelial cells by disrupting polyubiquitination and degradation of I?B? |pdf=|usr=}}{{27212040 }} gab.com Text Honokiol suppresses TNF- -induced neutrophil adhesion on cerebral endothelial cells by disrupting polyubiquitination and degradation of I B JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27212040 #FOAvip Adhesion molecules expressed on cerebral endothelial cells (ECs) mediate leukocyte recruitment and play a significant role in cerebral inflammation. Increased levels of adhesion molecules on the EC surface induce leukocyte infiltration into inflammatory areas and are thus hallmarkers of inflammation. Honokiol, isolated from the Chinese medicinal herb Magnolia officinalis, has various pharmacological activities, including anti-inflammatory effects, yet the nature of honokiol targeting molecules remains to be revealed. Here, we investigated the inhibitory effect of honokiol on neutrophil adhesion and vascular cell adhesion molecule-1 (VCAM-1) expression, which underlie its molecular target, and mechanisms for inactivating nuclear factor ? enhancer binding protein (NF-?B) in mouse cerebral ECs. Honokiol inhibited tumour necrosis factor-? (TNF-?)-induced neutrophil adhesion and VCAM-1 gene expression in cerebral ECs. The inflammatory transcription factor NF-?B was downregulated by honokiol. Honokiol significantly blocked TNF-?-induced NF-?B p65 nuclear translocation and degradation of the proteasome-dependent inhibitor of NF-?B ? (I?B?). From docking model prediction, honokiol directly targeted the ubiquitin-ubiquitin interface of Lys48-linked polychains. Moreover, honokiol prevented the TNF-?-induced Lys48-linked polyubiquitination, including I?B?-polyubiquitin interaction. Honokiol has protective anti-inflammatory effects on TNF-?-induced neutrophil adhesion and VCAM-1 gene expression in cerebral ECs, at least in part by directly inhibiting ubiquitination-mediated I?B? degradation and then preventing NF-?B nuclear translocation. Twit Text FOAVip Honokiol suppresses TNF- -induced neutrophil adhesion on cerebral endothelial cells by disrupting polyubiquitination and degradation of I B ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27212040 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27212040 #FOAvip English Wikipedia <ref>{{Cite pmid|27212040 }}</ref> Honokiol suppresses TNF-?-induced neutrophil adhesion on cerebral endothelial cells by disrupting polyubiquitination and degradation of I?B? #MMPMID27212040 Chen PJ ; Wang YL ; Kuo LM ; Lin CF ; Chen CY ; Tsai YF ; Shen JJ ; Hwang TL Sci Rep 2016[May]; 6 (ä): 26554 PMID27212040 show ga Adhesion molecules expressed on cerebral endothelial cells (ECs) mediate leukocyte recruitment and play a significant role in cerebral inflammation. Increased levels of adhesion molecules on the EC surface induce leukocyte infiltration into inflammatory areas and are thus hallmarkers of inflammation. Honokiol, isolated from the Chinese medicinal herb Magnolia officinalis, has various pharmacological activities, including anti-inflammatory effects, yet the nature of honokiol targeting molecules remains to be revealed. Here, we investigated the inhibitory effect of honokiol on neutrophil adhesion and vascular cell adhesion molecule-1 (VCAM-1) expression, which underlie its molecular target, and mechanisms for inactivating nuclear factor ? enhancer binding protein (NF-?B) in mouse cerebral ECs. Honokiol inhibited tumour necrosis factor-? (TNF-?)-induced neutrophil adhesion and VCAM-1 gene expression in cerebral ECs. The inflammatory transcription factor NF-?B was downregulated by honokiol. Honokiol significantly blocked TNF-?-induced NF-?B p65 nuclear translocation and degradation of the proteasome-dependent inhibitor of NF-?B ? (I?B?). From docking model prediction, honokiol directly targeted the ubiquitin-ubiquitin interface of Lys48-linked polychains. Moreover, honokiol prevented the TNF-?-induced Lys48-linked polyubiquitination, including I?B?-polyubiquitin interaction. Honokiol has protective anti-inflammatory effects on TNF-?-induced neutrophil adhesion and VCAM-1 gene expression in cerebral ECs, at least in part by directly inhibiting ubiquitination-mediated I?B? degradation and then preventing NF-?B nuclear translocation. |Animals [MESH] |Biphenyl Compounds/*pharmacology [MESH] |Brain/*cytology [MESH] |Cell Adhesion/drug effects [MESH] |Cells, Cultured [MESH] |Endothelial Cells/cytology [MESH] |Gene Expression Regulation/drug effects [MESH] |Humans [MESH] |Lignans/*pharmacology [MESH] |Mice [MESH] |NF-KappaB Inhibitor alpha/chemistry/*metabolism [MESH] |Neutrophils/*cytology/drug effects [MESH] |Proteolysis/drug effects [MESH] |Tumor Necrosis Factor-alpha/*metabolism [MESH] |Ubiquitination/drug effects [MESH]Honokiol suppresses TNF-?-induced neutrophil adhesion on cerebral endo(epmc).pdf DeepDyve Pubget Overpricing