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10.1055/s-0030-1262215

http://scihub22266oqcxt.onion/10.1055/s-0030-1262215
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C4876288!4876288!20665397
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suck abstract from ncbi


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pmid20665397      Semin+Respir+Crit+Care+Med 2010 ; 31 (4): 474-84
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  • Calcium and Vitamin D in Sarcoidosis: How to Assess and Manage #MMPMID20665397
  • Burke RR; Rybicki BA; Rao DS
  • Semin Respir Crit Care Med 2010[Aug]; 31 (4): 474-84 PMID20665397show ga
  • The synthesis of vitamin D is altered by the granulomatous inflammation of sarcoidosis leading to increased production of 1, 25-dihydroxyvitamin D. Mounting evidence suggests that vitamin D is an immunomodulating hormone that inhibits both antigen presentation by cells of the innate immune system, and the cytokine release and proliferation of Th1 cells. These and other extraskeletal health benefits have led to an increase in vitamin D assessment and pharmacological supplementation in the general population. This review highlights the altered synthesis and general immunomodulating properties of vitamin D with a special emphasis on known interactions with sarcoidosis. In addition, the assessment of vitamin D nutritional status, its pharmacological supplementation, and the management of bone health in patients with sarcoidosis are reviewed.
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