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10.1111/bcp.12882 http://scihub22266oqcxt.onion/10.1111/bcp.12882 C4876181!4876181!26750458     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Clin+Pharmacol 2016 ; 81 (6): 1037-45 Nephropedia Template TP {{tp|p=26750458|t=2016. Rotigaptide protects the myocardium and arterial vasculature from ischaemia reperfusion injury |pdf=|usr=}}{{26750458}} gab.com Text Rotigaptide protects the myocardium and arterial vasculature from ischaemia reperfusion injury JO: Br J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26750458 #FOAvip Aim: Ischaemia?reperfusion injury (IRI) causes impaired endothelial function and is a major component of the adverse effects of reperfusion following myocardial infarction. Rotigaptide increases gap junction conductance via connexin?43. We tested the hypothesis that rotigaptide reduces experimental myocardial infarction size and ameliorates endothelial IRI in humans. Methods: Myocardial infarction study: porcine myocardial infarction was achieved by catheter?induced occlusion of the left anterior descending artery. In a randomized double?blind study, rotigaptide (n = 9) or placebo (n = 10) was administered intravenously as a 10 min bolus prior to reperfusion and continuously during 2 h of reperfusion. Myocardial infarction size (IS) was assessed as proportion of the area at risk (AAR). Human translational study: forearm IRI was induced in the presence or absence of intra?arterial rotigaptide. In a randomized double?blind study, forearm arterial blood flow was measured at rest and during intra?arterial infusion of acetylcholine (5?20 ?g min?1; n = 11) or sodium nitroprusside (2?8 mg min?1; n = 10) before and after intra?arterial infusion of placebo or rotigaptide, and again following IRI. Results: Myocardial infarction study: Rotigaptide treatment was associated with a reduction of infarct size (IS/AAR[%]: 18.7 ± 4.1 [rotigaptide] vs. 43.6 ± 4.2 [placebo], P = 0.006). Human translational study: Endothelium?dependent vasodilatation to acetylcholine was attenuated after ischaemia?reperfusion in the presence of placebo (P = 0.007), but not in the presence of rotigaptide (P = NS). Endothelium?independent vasodilatation evoked by sodium nitroprusside was unaffected by IRI or rotigaptide (P = NS). Conclusions: Rotigaptide reduces myocardial infarction size in a porcine model and protects from IRI?related endothelial dysfunction in man. Rotigaptide may have therapeutic potential in the treatment of myocardial infarction. Twit Text FOAVip Rotigaptide protects the myocardium and arterial vasculature from ischaemia reperfusion injury ????Br J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26750458 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26750458 #FOAvip English Wikipedia <ref>{{Cite pmid|26750458}}</ref> Rotigaptide protects the myocardium and arterial vasculature from ischaemia reperfusion injury #MMPMID26750458 Pedersen CM; Venkatasubramanian S; Vase H; Hyldebrandt JA; Contractor H; Schmidt MR; Bøtker HE; Cruden NL; Newby DE; Kharbanda RK; Lang NN Br J Clin Pharmacol 2016[Jun]; 81 (6): 1037-45 PMID26750458show ga Aim: Ischaemia?reperfusion injury (IRI) causes impaired endothelial function and is a major component of the adverse effects of reperfusion following myocardial infarction. Rotigaptide increases gap junction conductance via connexin?43. We tested the hypothesis that rotigaptide reduces experimental myocardial infarction size and ameliorates endothelial IRI in humans. Methods: Myocardial infarction study: porcine myocardial infarction was achieved by catheter?induced occlusion of the left anterior descending artery. In a randomized double?blind study, rotigaptide (n = 9) or placebo (n = 10) was administered intravenously as a 10 min bolus prior to reperfusion and continuously during 2 h of reperfusion. Myocardial infarction size (IS) was assessed as proportion of the area at risk (AAR). Human translational study: forearm IRI was induced in the presence or absence of intra?arterial rotigaptide. In a randomized double?blind study, forearm arterial blood flow was measured at rest and during intra?arterial infusion of acetylcholine (5?20 ?g min?1; n = 11) or sodium nitroprusside (2?8 mg min?1; n = 10) before and after intra?arterial infusion of placebo or rotigaptide, and again following IRI. Results: Myocardial infarction study: Rotigaptide treatment was associated with a reduction of infarct size (IS/AAR[%]: 18.7 ± 4.1 [rotigaptide] vs. 43.6 ± 4.2 [placebo], P = 0.006). Human translational study: Endothelium?dependent vasodilatation to acetylcholine was attenuated after ischaemia?reperfusion in the presence of placebo (P = 0.007), but not in the presence of rotigaptide (P = NS). Endothelium?independent vasodilatation evoked by sodium nitroprusside was unaffected by IRI or rotigaptide (P = NS). Conclusions: Rotigaptide reduces myocardial infarction size in a porcine model and protects from IRI?related endothelial dysfunction in man. Rotigaptide may have therapeutic potential in the treatment of myocardial infarction. äRotigaptide protects the myocardium and arterial vasculature from isch(epmc).pdf DeepDyve Pubget Overpricing