Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27183573
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27183573
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Immunol
2016 ; 196
(11
): 4641-9
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Heme Oxygenase-1 Regulates Inflammation and Mycobacterial Survival in Human
Macrophages during Mycobacterium tuberculosis Infection
#MMPMID27183573
Scharn CR
; Collins AC
; Nair VR
; Stamm CE
; Marciano DK
; Graviss EA
; Shiloh MU
J Immunol
2016[Jun]; 196
(11
): 4641-9
PMID27183573
show ga
Mycobacterium tuberculosis, the causative agent of tuberculosis, is responsible
for 1.5 million deaths annually. We previously showed that M. tuberculosis
infection in mice induces expression of the CO-producing enzyme heme oxygenase
(HO1) and that CO is sensed by M. tuberculosis to initiate a dormancy program.
Further, mice deficient in HO1 succumb to M. tuberculosis infection more readily
than do wild-type mice. Although mouse macrophages control intracellular M.
tuberculosis infection through several mechanisms, such as NO synthase, the
respiratory burst, acidification, and autophagy, how human macrophages control M.
tuberculosis infection remains less well understood. In this article, we show
that M. tuberculosis induces and colocalizes with HO1 in both mouse and human
tuberculosis lesions in vivo, and that M. tuberculosis induces and colocalizes
with HO1 during primary human macrophage infection in vitro. Surprisingly, we
find that chemical inhibition of HO1 both reduces inflammatory cytokine
production by human macrophages and restricts intracellular growth of
mycobacteria. Thus, induction of HO1 by M. tuberculosis infection may be a
mycobacterial virulence mechanism to enhance inflammation and bacterial growth.
free
free
free
