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10.1093/emph/eow014 http://scihub22266oqcxt.onion/10.1093/emph/eow014 C4875775!4875775!27121451     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Evol+Med+Public+Health 2016 ; 2016 (1): 170-6 Nephropedia Template TP {{tp|p=27121451|t=2016. Mouse models of human disease: An evolutionary perspective |pdf=|usr=}}{{27121451}} gab.com Text Mouse models of human disease: An evolutionary perspective JO: Evol Med Public Health http://www.kidney.de/pget.php?&tw=1&pmid=27121451 #FOAvip The use of mice as model organisms to study human biology is predicated on the genetic and physiological similarities between the species. Nonetheless, mice and humans have evolved in and become adapted to different environments and so, despite their phylogenetic relatedness, they have become very different organisms. Mice often respond to experimental interventions in ways that differ strikingly from humans. Mice are invaluable for studying biological processes that have been conserved during the evolution of the rodent and primate lineages and for investigating the developmental mechanisms by which the conserved mammalian genome gives rise to a variety of different species. Mice are less reliable as models of human disease, however, because the networks linking genes to disease are likely to differ between the two species. The use of mice in biomedical research needs to take account of the evolved differences as well as the similarities between mice and humans. Twit Text FOAVip Mouse models of human disease: An evolutionary perspective ????Evol Med Public Health http://www.kidney.de/pget.php?&tw=1&pmid=27121451 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27121451 #FOAvip English Wikipedia <ref>{{Cite pmid|27121451}}</ref> Mouse models of human disease: An evolutionary perspective #MMPMID27121451 Perlman RL Evol Med Public Health 2016[]; 2016 (1): 170-6 PMID27121451show ga The use of mice as model organisms to study human biology is predicated on the genetic and physiological similarities between the species. Nonetheless, mice and humans have evolved in and become adapted to different environments and so, despite their phylogenetic relatedness, they have become very different organisms. Mice often respond to experimental interventions in ways that differ strikingly from humans. Mice are invaluable for studying biological processes that have been conserved during the evolution of the rodent and primate lineages and for investigating the developmental mechanisms by which the conserved mammalian genome gives rise to a variety of different species. Mice are less reliable as models of human disease, however, because the networks linking genes to disease are likely to differ between the two species. The use of mice in biomedical research needs to take account of the evolved differences as well as the similarities between mice and humans. äMouse models of human disease: An evolutionary perspective (epmc).pdf DeepDyve Pubget Overpricing