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10.1007/s13238-012-2938-0

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C4875361!4875361!22729398
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suck abstract from ncbi


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pmid22729398      Protein+Cell 2012 ; 3 (8): 618-26
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  • Bulk-like endocytosis plays an important role in the recycling of insulin granules in pancreatic beta cells #MMPMID22729398
  • Wen D; Xue Y; Liang K; Yuan T; Lu J; Zhao W; Xu T; Chen L
  • Protein Cell 2012[Aug]; 3 (8): 618-26 PMID22729398show ga
  • Although bulk endocytosis has been found in a number of neuronal and endocrine cells, the molecular mechanism and physiological function of bulk endocytosis remain elusive. In pancreatic beta cells, we have observed bulk-like endocytosis evoked both by flash photolysis and trains of depolarization. Bulk-like endocytosis is a clathrin-independent process that is facilitated by enhanced extracellular Ca2+ entry and suppressed by the inhibition of dynamin function. Moreover, defects in bulk-like endocytosis are accompanied by hyperinsulinemia in primary beta cells dissociated from diabetic KKAy mice, which suggests that bulk-like endocytosis plays an important role in maintaining the exo-endocytosis balance and beta cell secretory capability.
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