Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1007/s13238-011-1006-5 http://scihub22266oqcxt.onion/10.1007/s13238-011-1006-5 C4875287!4875287!21337007     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Protein+Cell 2011 ; 2 (1): 26-40 Nephropedia Template TP {{tp|p=21337007|t=2011. Structure and function of interleukin-17 family cytokines |pdf=|usr=}}{{21337007}} gab.com Text Structure and function of interleukin-17 family cytokines JO: Protein Cell http://www.kidney.de/pget.php?&tw=1&pmid=21337007 #FOAvip The recently identified interleukin-17 (IL-17) cytokines family, which comprises six members in mammals (IL-17A-F), plays essential roles in the host immunity against infectious diseases and chronic inflammatory diseases. The three-dimensional structures containing IL-17A or IL-17F have become available and revealed the unique structural features of IL-17s as well as their receptors. Molecular modeling in this review shows that IL-17s may adopt a ?cysteine knot? fold commonly seen in nerve growth factor (NGF) and other neurotrophins. Further modeling analysis unmasks a signature interaction feature of the IL-17F/IL-17RA complex, where a small loop of IL-17RA slots into the deep groove of the interface of IL-17F homodimer. This is quite different from the interaction between the best known four-helix cytokines and their cognate receptors. On the other hand, structure of IL-17A and its monoclonal antibody (CAT-2200) shows that, albeit that the antigenic epitope of IL-17A resides outside of the IL-17A homodimer interface, its physical proximity to the receptor binding groove may explain that antibody blockage would be achieved by interfering with the ligand-receptor interaction. This review is to summarize the advance in understanding the structure and function of IL-17 family cytokines, focusing mainly on IL-17A, IL-17F and IL-17E, in the hope of gaining better knowledge of immunotherapeutic strategies against various inflammatory diseases.Electronic Supplementary Material: Supplementary material is available for this article at 10.1007/s13238-011-1006-5 and is accessible for authorized users. Twit Text FOAVip Structure and function of interleukin-17 family cytokines ????Protein Cell http://www.kidney.de/pget.php?&tw=1&pmid=21337007 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21337007 #FOAvip English Wikipedia <ref>{{Cite pmid|21337007}}</ref> Structure and function of interleukin-17 family cytokines #MMPMID21337007 Zhang X; Angkasekwinai P; Dong C; Tang H Protein Cell 2011[Jan]; 2 (1): 26-40 PMID21337007show ga The recently identified interleukin-17 (IL-17) cytokines family, which comprises six members in mammals (IL-17A-F), plays essential roles in the host immunity against infectious diseases and chronic inflammatory diseases. The three-dimensional structures containing IL-17A or IL-17F have become available and revealed the unique structural features of IL-17s as well as their receptors. Molecular modeling in this review shows that IL-17s may adopt a ?cysteine knot? fold commonly seen in nerve growth factor (NGF) and other neurotrophins. Further modeling analysis unmasks a signature interaction feature of the IL-17F/IL-17RA complex, where a small loop of IL-17RA slots into the deep groove of the interface of IL-17F homodimer. This is quite different from the interaction between the best known four-helix cytokines and their cognate receptors. On the other hand, structure of IL-17A and its monoclonal antibody (CAT-2200) shows that, albeit that the antigenic epitope of IL-17A resides outside of the IL-17A homodimer interface, its physical proximity to the receptor binding groove may explain that antibody blockage would be achieved by interfering with the ligand-receptor interaction. This review is to summarize the advance in understanding the structure and function of IL-17 family cytokines, focusing mainly on IL-17A, IL-17F and IL-17E, in the hope of gaining better knowledge of immunotherapeutic strategies against various inflammatory diseases.Electronic Supplementary Material: Supplementary material is available for this article at 10.1007/s13238-011-1006-5 and is accessible for authorized users. äStructure and function of interleukin-17 family cytokines (epmc).pdf DeepDyve Pubget Overpricing