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10.1016/j.tim.2016.02.010

http://scihub22266oqcxt.onion/10.1016/j.tim.2016.02.010
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suck abstract from ncbi


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pmid26968354      Trends+Microbiol 2016 ; 24 (6): 477-89
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  • Dancing with the Stars: how Choreographed Bacterial Interactions Dictate Nososymbiocity and Give Rise to Keystone Pathogens, Accessory Pathogens, and Pathobionts #MMPMID26968354
  • Hajishengallis G; Lamont RJ
  • Trends Microbiol 2016[Jun]; 24 (6): 477-89 PMID26968354show ga
  • Many diseases that originate on mucosal membranes ensue from the action of polymicrobial communities of indigenous organisms working in concert to disrupt homeostatic mechanisms. Multi-level physical and chemical communication systems among constituent organisms underlies polymicrobial synergy and dictates the community?s pathogenic potential or nososymbiocity, that is, disease arising from living together with a susceptible host. Functional specialization of community participants, often originating from metabolic co-dependence, has given rise to several newly appreciated designations within the commensal-to-pathogen spectrum. Accessory pathogens, while inherently commensal in a particular microenvironment, nonetheless enhance the colonization or metabolic activity of pathogens. Keystone pathogens (bacterial drivers or alpha-bugs) exert their influence at low abundance by modulating both the composition and levels of community participants and by manipulating host responses. Pathobionts (or bacterial passengers) exploit disrupted host homeostasis to flourish and promote inflammatory disease. In this review we will discuss how commensal or pathogenic properties of organisms are not intrinsic features, and have to be considered within the context of both the microbial community in which they reside and the host immune status.
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