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10.1002/smll.201600194 http://scihub22266oqcxt.onion/10.1002/smll.201600194 C4874869!4874869!27062146     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Small 2016 ; 12 (20): 2775-82 Nephropedia Template TP {{tp|p=27062146|t=2016. Dynamic Positron Emission Tomography Imaging of Renal Clearable Gold Nanoparticles |pdf=|usr=}}{{27062146}} gab.com Text Dynamic Positron Emission Tomography Imaging of Renal Clearable Gold Nanoparticles JO: Small http://www.kidney.de/pget.php?&tw=1&pmid=27062146 #FOAvip Optical imaging has been the primary imaging modality for nearly all of the renal clearable nanoparticles since 2007. Due to the tissue depth penetration limitation, providing accurate organ kinetics non-invasively has long been a huge challenge. Although a more quantitative imaging technique has been developed by labeling nanoparticles with single-photon emission computed tomography (SPECT) isotopes, the low temporal resolution of SPECT still limits its potential for visualizing the rapid dynamic process of renal clearable nanoparticles in vivo. Here, we report the dynamic positron emission tomography (PET) imaging of renal clearable gold (Au) nanoparticles by labeling them with copper-64 (64Cu) to form 64Cu-NOTA-Au-GSH. Systematic nanoparticle synthesis and characterizations were performed to demonstrate the efficient renal clearance of as-prepared nanoparticles. A rapid renal clearance of 64Cu-NOTA-Au-GSH was observed (>75 %ID at 24 h post-injection) with its elimination half-life calculated to be less than 6 min, over 130 times shorter than previously reported similar nanoparticles. Dynamic PET imaging not only addresses the current challenges in accurately and non-invasively acquiring the organ kinetics, but also potentially provides a highly useful tool for studying renal clearance mechanism of other ultra-small nanoparticles, as well as the diagnosis of kidney diseases in the near future. Twit Text FOAVip Dynamic Positron Emission Tomography Imaging of Renal Clearable Gold Nanoparticles ????Small http://www.kidney.de/pget.php?&tw=1&pmid=27062146 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27062146 #FOAvip English Wikipedia <ref>{{Cite pmid|27062146}}</ref> Dynamic Positron Emission Tomography Imaging of Renal Clearable Gold Nanoparticles #MMPMID27062146 Chen F; Goel S; Hernandez R; Graves SA; Shi S; Nickles RJ; Cai W Small 2016[May]; 12 (20): 2775-82 PMID27062146show ga Optical imaging has been the primary imaging modality for nearly all of the renal clearable nanoparticles since 2007. Due to the tissue depth penetration limitation, providing accurate organ kinetics non-invasively has long been a huge challenge. Although a more quantitative imaging technique has been developed by labeling nanoparticles with single-photon emission computed tomography (SPECT) isotopes, the low temporal resolution of SPECT still limits its potential for visualizing the rapid dynamic process of renal clearable nanoparticles in vivo. Here, we report the dynamic positron emission tomography (PET) imaging of renal clearable gold (Au) nanoparticles by labeling them with copper-64 (64Cu) to form 64Cu-NOTA-Au-GSH. Systematic nanoparticle synthesis and characterizations were performed to demonstrate the efficient renal clearance of as-prepared nanoparticles. A rapid renal clearance of 64Cu-NOTA-Au-GSH was observed (>75 %ID at 24 h post-injection) with its elimination half-life calculated to be less than 6 min, over 130 times shorter than previously reported similar nanoparticles. Dynamic PET imaging not only addresses the current challenges in accurately and non-invasively acquiring the organ kinetics, but also potentially provides a highly useful tool for studying renal clearance mechanism of other ultra-small nanoparticles, as well as the diagnosis of kidney diseases in the near future. äDynamic Positron Emission Tomography Imaging of Renal Clearable Gold N(epmc).pdf DeepDyve Pubget Overpricing