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10.1016/j.cell.2016.04.014 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.04.014 C4874868!4874868!27156452     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27156452&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2016 ; 165 (5): 1134-46 Nephropedia Template TP {{tp|p=27156452|t=2016. Distinct Gene Regulatory Pathways for Human Innate Versus Adaptive Lymphoid Cells |pdf=|usr=}}{{27156452}} gab.com Text Distinct Gene Regulatory Pathways for Human Innate Versus Adaptive Lymphoid Cells JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=27156452 #FOAvip Innate lymphoid cells (ILCs) serve as sentinels in mucosal tissues, sensing release of soluble inflammatory mediators, rapidly communicating danger via cytokine secretion, and functioning as guardians of tissue homeostasis. Although ILCs have been studied extensively in model organisms, little is known about these ?first responders? in humans, especially their lineage and functional kinships to cytokine-secreting T helper (Th) cell counterparts. Here, we report gene regulatory circuitries for four human ILC?Th counterparts derived from mucosal environments, revealing that each ILC subset diverges as a distinct lineage from Th and circulating natural killer cells, but shares circuitry devoted to functional polarization with their Th counterparts. Super-enhancers demarcate cohorts of cell identity genes in each lineage, uncovering new modes of regulation for signature cytokines, new molecules that likely impart important functions to ILCs, and potential mechanisms for autoimmune disease SNP associations within ILC?Th subsets. Twit Text FOAVip Distinct Gene Regulatory Pathways for Human Innate Versus Adaptive Lymphoid Cells ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=27156452 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27156452 #FOAvip English Wikipedia <ref>{{Cite pmid|27156452}}</ref> Distinct Gene Regulatory Pathways for Human Innate Versus Adaptive Lymphoid Cells #MMPMID27156452 Koues OI; Collins PL; Cella M; Robinette ML; Porter SI; Pyfrom SC; Payton JE; Colonna M; Oltz EM Cell 2016[May]; 165 (5): 1134-46 PMID27156452show ga Innate lymphoid cells (ILCs) serve as sentinels in mucosal tissues, sensing release of soluble inflammatory mediators, rapidly communicating danger via cytokine secretion, and functioning as guardians of tissue homeostasis. Although ILCs have been studied extensively in model organisms, little is known about these ?first responders? in humans, especially their lineage and functional kinships to cytokine-secreting T helper (Th) cell counterparts. Here, we report gene regulatory circuitries for four human ILC?Th counterparts derived from mucosal environments, revealing that each ILC subset diverges as a distinct lineage from Th and circulating natural killer cells, but shares circuitry devoted to functional polarization with their Th counterparts. Super-enhancers demarcate cohorts of cell identity genes in each lineage, uncovering new modes of regulation for signature cytokines, new molecules that likely impart important functions to ILCs, and potential mechanisms for autoimmune disease SNP associations within ILC?Th subsets. äDistinct Gene Regulatory Pathways for Human Innate Versus Adaptive Lym(epmc).pdf DeepDyve Pubget Overpricing