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10.1016/j.cell.2016.04.029 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.04.029 C4874839!4874839!27156451     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2016 ; 165 (5): 1120-33 Nephropedia Template TP {{tp|p=27156451|t=2016. Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality |pdf=|usr=}}{{27156451}} gab.com Text Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=27156451 #FOAvip Innate lymphoid cells (ILCs) play key roles in host defense, barrier integrity, and homeostasis, and they mirror adaptive CD4+ T helper (Th) cell subtypes in both usages of effector molecules and transcription factors. To better understand the relationship between ILC subsets and their Th cells counterparts, we measured genome-wide chromatin accessibility. We find that chromatin in proximity to effector genes is selectively accessible in ILCs prior to high-level transcription upon activation. Accessibility of these regions is acquired in a stepwise manner during development and changes little after in vitro or in vivo activation. Conversely, dramatic chromatin remodeling occurs in naïve CD4+ T cells during Th cell differentiation using a type 2-infection model. This alteration results in a substantial convergence of Th2 cells toward ILC2 regulomes. Our data indicate extensive sharing of regulatory circuitry across the innate and adaptive compartments of the immune system, in spite of their divergent developing pathways. Twit Text FOAVip Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=27156451 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27156451 #FOAvip English Wikipedia <ref>{{Cite pmid|27156451}}</ref> Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality #MMPMID27156451 Shih HY; Sciumè G; Mikami Y; Guo L; Sun HW; Brooks SR; Urban JF; Davis FP; Kanno Y; O?Shea JJ Cell 2016[May]; 165 (5): 1120-33 PMID27156451show ga Innate lymphoid cells (ILCs) play key roles in host defense, barrier integrity, and homeostasis, and they mirror adaptive CD4+ T helper (Th) cell subtypes in both usages of effector molecules and transcription factors. To better understand the relationship between ILC subsets and their Th cells counterparts, we measured genome-wide chromatin accessibility. We find that chromatin in proximity to effector genes is selectively accessible in ILCs prior to high-level transcription upon activation. Accessibility of these regions is acquired in a stepwise manner during development and changes little after in vitro or in vivo activation. Conversely, dramatic chromatin remodeling occurs in naïve CD4+ T cells during Th cell differentiation using a type 2-infection model. This alteration results in a substantial convergence of Th2 cells toward ILC2 regulomes. Our data indicate extensive sharing of regulatory circuitry across the innate and adaptive compartments of the immune system, in spite of their divergent developing pathways. äDevelopmental Acquisition of Regulomes Underlies Innate Lymphoid Cell (epmc).pdf DeepDyve Pubget Overpricing