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10.1172/jci.insight.86252 http://scihub22266oqcxt.onion/10.1172/jci.insight.86252 C4874509!4874509!27213183     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight ä ; 1 (5): ä Nephropedia Template TP {{tp|p=27213183|t=ä. Origin and evolution of the T cell repertoire after posttransplantation cyclophosphamide |pdf=|usr=}}{{27213183}} gab.com Text Origin and evolution of the T cell repertoire after posttransplantation cyclophosphamide JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=27213183 #FOAvip Posttransplantation cyclophosphamide (PTCy) effectively prevents graft-versus-host disease (GVHD), but its immunologic impact is poorly understood. We assessed lymphocyte reconstitution via flow cytometry (n = 74) and antigen receptor sequencing (n = 35) in recipients of myeloablative, HLA-matched allogeneic BM transplantation using PTCy. Recovering T cells were primarily phenotypically effector memory with lower T cell receptor ? (TRB) repertoire diversity than input donor repertoires. Recovering B cells were predominantly naive with immunoglobulin heavy chain locus (IGH) repertoire diversity similar to donors. Numerical T cell reconstitution and TRB diversity were strongly associated with recipient cytomegalovirus seropositivity. Global similarity between input donor and recipient posttransplant repertoires was uniformly low at 1?2 months after transplant but increased over the balance of the first posttransplant year. Blood TRB repertoires at ?3 months after transplant were often dominated by clones present in the donor blood/marrow memory CD8+ compartment. Limited overlap was observed between the TRB repertoires of T cells infiltrating the skin or gastrointestinal tract versus the blood. Although public TRB sequences associated with herpesvirus- or alloantigen-specific CD8+ T cells were detected in some patients, posttransplant TRB and IGH repertoires were unique to each individual. These data define the immune dynamics occurring after PTCy and establish a benchmark against which immune recovery after other transplantation approaches can be compared. Twit Text FOAVip Origin and evolution of the T cell repertoire after posttransplantation cyclophosphamide ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=27213183 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27213183 #FOAvip English Wikipedia <ref>{{Cite pmid|27213183}}</ref> Origin and evolution of the T cell repertoire after posttransplantation cyclophosphamide #MMPMID27213183 Kanakry CG; Coffey DG; Towlerton AM; Vulic A; Storer BE; Chou J; Yeung CC; Gocke CD; Robins HS; O?Donnell PV; Luznik L; Warren EH JCI Insight ä[]; 1 (5): ä PMID27213183show ga Posttransplantation cyclophosphamide (PTCy) effectively prevents graft-versus-host disease (GVHD), but its immunologic impact is poorly understood. We assessed lymphocyte reconstitution via flow cytometry (n = 74) and antigen receptor sequencing (n = 35) in recipients of myeloablative, HLA-matched allogeneic BM transplantation using PTCy. Recovering T cells were primarily phenotypically effector memory with lower T cell receptor ? (TRB) repertoire diversity than input donor repertoires. Recovering B cells were predominantly naive with immunoglobulin heavy chain locus (IGH) repertoire diversity similar to donors. Numerical T cell reconstitution and TRB diversity were strongly associated with recipient cytomegalovirus seropositivity. Global similarity between input donor and recipient posttransplant repertoires was uniformly low at 1?2 months after transplant but increased over the balance of the first posttransplant year. Blood TRB repertoires at ?3 months after transplant were often dominated by clones present in the donor blood/marrow memory CD8+ compartment. Limited overlap was observed between the TRB repertoires of T cells infiltrating the skin or gastrointestinal tract versus the blood. Although public TRB sequences associated with herpesvirus- or alloantigen-specific CD8+ T cells were detected in some patients, posttransplant TRB and IGH repertoires were unique to each individual. These data define the immune dynamics occurring after PTCy and establish a benchmark against which immune recovery after other transplantation approaches can be compared. äOrigin and evolution of the T cell repertoire after posttransplantatio(epmc).pdf DeepDyve Pubget Overpricing