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10.1098/rstb.2015.0292

http://scihub22266oqcxt.onion/10.1098/rstb.2015.0292
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C4874390!4874390!27160595
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suck abstract from ncbi


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pmid27160595      Philos+Trans+R+Soc+Lond+B+Biol+Sci 2016 ; 371 (1695): ä
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  • Bacterial strategies of resistance to antimicrobial peptides #MMPMID27160595
  • Joo HS; Fu CI; Otto M
  • Philos Trans R Soc Lond B Biol Sci 2016[May]; 371 (1695): ä PMID27160595show ga
  • Antimicrobial peptides (AMPs) are a key component of the host's innate immune system, targeting invasive and colonizing bacteria. For successful survival and colonization of the host, bacteria have a series of mechanisms to interfere with AMP activity, and AMP resistance is intimately connected with the virulence potential of bacterial pathogens. In particular, because AMPs are considered as potential novel antimicrobial drugs, it is vital to understand bacterial AMP resistance mechanisms. This review gives a comparative overview of Gram-positive and Gram-negative bacterial strategies of resistance to various AMPs, such as repulsion or sequestration by bacterial surface structures, alteration of membrane charge or fluidity, degradation and removal by efflux pumps.This article is part of the themed issue ?Evolutionary ecology of arthropod antimicrobial peptides?.
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