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10.1182/blood-2015-10-673681 http://scihub22266oqcxt.onion/10.1182/blood-2015-10-673681 C4874228!4874228 !26862110     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26862110 &cmd=llinks): Failed to open stream: HTTP request failed! 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Clinical and laboratory variability in a cohort of patients diagnosed with type 1 VWD in the United States |pdf=|usr=}}{{26862110 }} gab.com Text Clinical and laboratory variability in a cohort of patients diagnosed with type 1 VWD in the United States JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=26862110 #FOAvip von Willebrand disease (VWD) is the most common inherited bleeding disorder, and type 1 VWD is the most common VWD variant. Despite its frequency, diagnosis of type 1 VWD remains the subject of debate. In order to study the spectrum of type 1 VWD in the United States, the Zimmerman Program enrolled 482 subjects with a previous diagnosis of type 1 VWD without stringent laboratory diagnostic criteria. von Willebrand factor (VWF) laboratory testing and full-length VWF gene sequencing was performed for all index cases and healthy control subjects in a central laboratory. Bleeding phenotype was characterized using the International Society on Thrombosis and Haemostasis bleeding assessment tool. At study entry, 64% of subjects had VWF antigen (VWF:Ag) or VWF ristocetin cofactor activity below the lower limit of normal, whereas 36% had normal VWF levels. VWF sequence variations were most frequent in subjects with VWF:Ag <30 IU/dL (82%), whereas subjects with type 1 VWD and VWF:Ag ?30 IU/dL had an intermediate frequency of variants (44%). Subjects whose VWF testing was normal at study entry had a similar rate of sequence variations as the healthy controls (14%). All subjects with severe type 1 VWD and VWF:Ag ?5 IU/dL had an abnormal bleeding score (BS), but otherwise BS did not correlate with VWF:Ag. Subjects with a historical diagnosis of type 1 VWD had similar rates of abnormal BS compared with subjects with low VWF levels at study entry. Type 1 VWD in the United States is highly variable, and bleeding symptoms are frequent in this population. Twit Text FOAVip Clinical and laboratory variability in a cohort of patients diagnosed with type 1 VWD in the United States ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=26862110 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26862110 #FOAvip English Wikipedia <ref>{{Cite pmid|26862110 }}</ref> Clinical and laboratory variability in a cohort of patients diagnosed with type 1 VWD in the United States #MMPMID26862110 Flood VH ; Christopherson PA ; Gill JC ; Friedman KD ; Haberichter SL ; Bellissimo DB ; Udani RA ; Dasgupta M ; Hoffmann RG ; Ragni MV ; Shapiro AD ; Lusher JM ; Lentz SR ; Abshire TC ; Leissinger C ; Hoots WK ; Manco-Johnson MJ ; Gruppo RA ; Boggio LN ; Montgomery KT ; Goodeve AC ; James PD ; Lillicrap D ; Peake IR ; Montgomery RR Blood 2016[May]; 127 (20 ): 2481-8 PMID26862110 show ga von Willebrand disease (VWD) is the most common inherited bleeding disorder, and type 1 VWD is the most common VWD variant. Despite its frequency, diagnosis of type 1 VWD remains the subject of debate. In order to study the spectrum of type 1 VWD in the United States, the Zimmerman Program enrolled 482 subjects with a previous diagnosis of type 1 VWD without stringent laboratory diagnostic criteria. von Willebrand factor (VWF) laboratory testing and full-length VWF gene sequencing was performed for all index cases and healthy control subjects in a central laboratory. Bleeding phenotype was characterized using the International Society on Thrombosis and Haemostasis bleeding assessment tool. At study entry, 64% of subjects had VWF antigen (VWF:Ag) or VWF ristocetin cofactor activity below the lower limit of normal, whereas 36% had normal VWF levels. VWF sequence variations were most frequent in subjects with VWF:Ag <30 IU/dL (82%), whereas subjects with type 1 VWD and VWF:Ag ?30 IU/dL had an intermediate frequency of variants (44%). Subjects whose VWF testing was normal at study entry had a similar rate of sequence variations as the healthy controls (14%). All subjects with severe type 1 VWD and VWF:Ag ?5 IU/dL had an abnormal bleeding score (BS), but otherwise BS did not correlate with VWF:Ag. Subjects with a historical diagnosis of type 1 VWD had similar rates of abnormal BS compared with subjects with low VWF levels at study entry. Type 1 VWD in the United States is highly variable, and bleeding symptoms are frequent in this population. |Adolescent [MESH] |Blood Coagulation Tests [MESH] |Comparative Genomic Hybridization [MESH] |Female [MESH] |Genetic Variation [MESH] |Hemorrhage/etiology [MESH] |Humans [MESH] |Male [MESH] |Phenotype [MESH] |Sequence Analysis, DNA [MESH] |Surveys and Questionnaires [MESH] |United States/epidemiology [MESH] |Young Adult [MESH] |von Willebrand Disease, Type 1/*blood/diagnosis/epidemiology [MESH]Clinical and laboratory variability in a cohort of patients diagnosed (epmc).pdf DeepDyve Pubget Overpricing