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2016 ; 78
(4
): 669-74
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Selenium supplementation restores the decreased albumin level of peripheral blood
mononuclear cells in streptozotocin-induced diabetic mice
#MMPMID26726102
Ahn T
; Bae CS
; Yun CH
J Vet Med Sci
2016[May]; 78
(4
): 669-74
PMID26726102
show ga
Previously, it has been suggested that the phenotypic level of albumin in
peripheral blood mononuclear cells (PBMC) decreased in streptozotocin
(STZ)-induced diabetic rats. Concomitantly, the production of oxidative stresses
was also elevated in the diabetic PBMC compared to that of normal control. These
results suggest the close relationship between PBMC-albumin and its antioxidant
roles. Here, we expanded the previous studies and investigated the effect of
selenium supplementation as inorganic (sodium selenate) forms on the levels of
albumin expression and oxidative stress in PBMC of STZ-induced diabetic mice.
Selenium intake recovered the decreased albumin levels to those of normal mice
and reduced the production of reactive oxygen species (ROS). These results
support that selenium intake may alleviate the etiology and pathology of PBMC in
type 1 diabetic mice by restoring the decrease in albumin contents and the
production of ROS.