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2016 ; 6
(ä): 26543
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Elevated plasma levels of Th17-related cytokines are associated with increased
risk of atrial fibrillation
#MMPMID27198976
Wu N
; Xu B
; Liu Y
; Chen X
; Tang H
; Wu L
; Xiang Y
; Zhang M
; Shu M
; Song Z
; Li Y
; Zhong L
Sci Rep
2016[May]; 6
(ä): 26543
PMID27198976
show ga
We performed a matched case-control study using a propensity score matching, to
assess the association of Th17-related cytokines, including interleukin (IL) 17A
(IL-17A), IL-17F, IL-21, IL-22 and IL-6, along with interferon-? (IFN-?), IL-10,
IL-9, and IL-4, with the risk of AF. A total of 336 patients with AF were matched
1:1 with patients without AF. Plasma levels of cytokines were measured using
Luminex xMAP assays. The plasma levels of all examined cytokines were
significantly higher in AF patients than controls (P?0.05), and these cytokines
were highly correlated with each other (P?0.01). A multivariate conditional
logistic regression analysis showed that elevated plasma levels of IL-17A,
IL-17F, IL-21, IL-22, IFN-?, IL-10, IL-9 and IL-6 were significantly associated
with AF risk independently of potential confounders. There were no significant
differences in plasma levels of examined cytokines between paroxysmal and chronic
AF patients. IL-17A, IL-21, IL-10 and IL-6 levels were positively correlated with
left atrial diameter; IL-17F level was negatively correlated with left ventricle
ejection fraction among AF patients (P?0.05). Elevated plasma levels of
Th17-related cytokines were independently associated with increased an risk of
AF; hence, Th17-related cytokines may be involved in the pathogenesis of AF.