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10.1038/srep26539 http://scihub22266oqcxt.onion/10.1038/srep26539 C4873744!4873744 !27198863     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27198863 &cmd=llinks): Failed to open stream: HTTP request failed! 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Proteinuria as a Therapeutic Target in Advanced Chronic Kidney Disease: a Retrospective Multicenter Cohort Study |pdf=|usr=}}{{27198863 }} gab.com Text Proteinuria as a Therapeutic Target in Advanced Chronic Kidney Disease: a Retrospective Multicenter Cohort Study JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27198863 #FOAvip Current evidence of proteinuria reduction as a surrogate target in advanced chronic kidney disease (CKD) is incomplete due to lack of patient-pooled database. We retrospectively studied a multicenter cohort of 1891 patients who were enrolled in the nationwide multidisciplinary pre-end stage renal disease care program with a baseline glomerular filtration rate (GFR) <45?mL/min/1.73?m(2) and followed longitudinally to investigate the effect of the change in proteinuria on renal death (defined as composite of dialysis and death occurring before initiation of dialysis). The group with a change in proteinuria ?0.30?g/g (n?=?1261) had lower cumulative probabilities of renal death (p?<?0.001). In a linear regression model, a higher baseline proteinuria and a greater increase in proteinuria were associated with faster annual GFR decline. Cox's analysis showed that every 1 unit increase in natural log(baseline proteinuria, 10?g/g) and every 0.1?g/g increase in the change in proteinuria resulted in 67% (HR?=?1.67, 95% CI: 1.46-1.91) and 1% (HR?=?1.01, 95% CI: 1.01-1.01) greater risk of renal death respectively after adjusting for the effects of the other covariates. Our study provided a patient-based evidence to support proteinuria as a therapeutic target in advanced CKD. Twit Text FOAVip Proteinuria as a Therapeutic Target in Advanced Chronic Kidney Disease: a Retrospective Multicenter Cohort Study ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27198863 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27198863 #FOAvip English Wikipedia <ref>{{Cite pmid|27198863 }}</ref> Proteinuria as a Therapeutic Target in Advanced Chronic Kidney Disease: a Retrospective Multicenter Cohort Study #MMPMID27198863 Chen CH ; Wu HY ; Wang CL ; Yang FJ ; Wu PC ; Hung SC ; Kan WC ; Yang CW ; Chiang CK ; Huang JW ; Hung KY Sci Rep 2016[May]; 6 (ä): 26539 PMID27198863 show ga Current evidence of proteinuria reduction as a surrogate target in advanced chronic kidney disease (CKD) is incomplete due to lack of patient-pooled database. We retrospectively studied a multicenter cohort of 1891 patients who were enrolled in the nationwide multidisciplinary pre-end stage renal disease care program with a baseline glomerular filtration rate (GFR) <45?mL/min/1.73?m(2) and followed longitudinally to investigate the effect of the change in proteinuria on renal death (defined as composite of dialysis and death occurring before initiation of dialysis). The group with a change in proteinuria ?0.30?g/g (n?=?1261) had lower cumulative probabilities of renal death (p? |Aged [MESH] |Aged, 80 and over [MESH] |Creatinine/*urine [MESH] |Disease Progression [MESH] |Evidence-Based Medicine [MESH] |Female [MESH] |Glomerular Filtration Rate [MESH] |Humans [MESH] |Linear Models [MESH] |Longitudinal Studies [MESH] |Male [MESH] |Middle Aged [MESH] |Proteinuria/drug therapy/etiology/*metabolism/physiopathology [MESH] |Renal Insufficiency, Chronic/complications/metabolism/*physiopathology [MESH] |Retrospective Studies [MESH] |Risk Factors [MESH]Proteinuria as a Therapeutic Target in Advanced Chronic Kidney Disease(epmc).pdf DeepDyve Pubget Overpricing