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10.1158/0008-5472.CAN-15-1885 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-15-1885 C4873432!4873432!26951929     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26951929&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2016 ; 76 (8): 2137-52 Nephropedia Template TP {{tp|p=26951929|t=2016. Agonist-mediated activation of STING induces apoptosis in malignant B cells |pdf=|usr=}}{{26951929}} gab.com Text Agonist-mediated activation of STING induces apoptosis in malignant B cells JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26951929 #FOAvip Endoplasmic reticulum (ER) stress responses through the IRE-1/XBP-1 pathway are required for the function of STING (TMEM173), an ER-resident transmembrane protein critical for cytoplasmic DNA sensing, interferon production and cancer control. Here we show that the IRE-1/XBP-1 pathway functions downstream of STING and that STING agonists selectively trigger mitochondria-mediated apoptosis in normal and malignant B cells. Upon stimulation, STING was degraded less efficiently in B cells, implying that prolonged activation of STING can lead to apoptosis. Transient activation of the IRE-1/XBP-1 pathway partially protected agonist-stimulated malignant B cells from undergoing apoptosis. In E?-TCL1 mice with chronic lymphocytic leukemia, injection of the STING agonist 3?3?-cGAMP induced apoptosis and tumor regression. Similarly efficacious effects were elicited by 3?3?-cGAMP injection in syngeneic or immunodeficient mice grafted with multiple myeloma. Thus, in addition to their established ability to boost anti-tumoral immune responses, STING agonists can also directly eradicate malignant B cells. Twit Text FOAVip Agonist-mediated activation of STING induces apoptosis in malignant B cells ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26951929 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26951929 #FOAvip English Wikipedia <ref>{{Cite pmid|26951929}}</ref> Agonist-mediated activation of STING induces apoptosis in malignant B cells #MMPMID26951929 Tang CHA; Zundell JA; Ranatunga S; Lin C; Nefedova Y; Del Valle JR; Hu CCA Cancer Res 2016[Apr]; 76 (8): 2137-52 PMID26951929show ga Endoplasmic reticulum (ER) stress responses through the IRE-1/XBP-1 pathway are required for the function of STING (TMEM173), an ER-resident transmembrane protein critical for cytoplasmic DNA sensing, interferon production and cancer control. Here we show that the IRE-1/XBP-1 pathway functions downstream of STING and that STING agonists selectively trigger mitochondria-mediated apoptosis in normal and malignant B cells. Upon stimulation, STING was degraded less efficiently in B cells, implying that prolonged activation of STING can lead to apoptosis. Transient activation of the IRE-1/XBP-1 pathway partially protected agonist-stimulated malignant B cells from undergoing apoptosis. In E?-TCL1 mice with chronic lymphocytic leukemia, injection of the STING agonist 3?3?-cGAMP induced apoptosis and tumor regression. Similarly efficacious effects were elicited by 3?3?-cGAMP injection in syngeneic or immunodeficient mice grafted with multiple myeloma. Thus, in addition to their established ability to boost anti-tumoral immune responses, STING agonists can also directly eradicate malignant B cells. äAgonist-mediated activation of STING induces apoptosis in malignant B (epmc).pdf DeepDyve Pubget Overpricing