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10.1158/0008-5472.CAN-15-2125 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-15-2125 C4873370!4873370!26988985     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2016 ; 76 (7): 1683-9 Nephropedia Template TP {{tp|p=26988985|t=2016. Combining Epigenetic and Immune Therapy to Combat Cancer |pdf=|usr=}}{{26988985}} gab.com Text Combining Epigenetic and Immune Therapy to Combat Cancer JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26988985 #FOAvip The most exciting recent advance for achieving durable management of advanced human cancers is immune therapy, especially the concept of immune checkpoint blockade. However, with the exception of melanoma, most patients do not respond to immune therapy alone. A growing body of work has shown that epigenetic drugs, specifically DNA methyltransferase inhibitors, can upregulate immune signaling in epithelial cancer cells through demethylation of endogenous retroviruses and cancer testis antigens. These demethylating agents may induce T-cell attraction and enhance immune checkpoint inhibitor efficacy in mouse models. Current clinical trials are testing this combination therapy as a potent new cancer management strategy. Twit Text FOAVip Combining Epigenetic and Immune Therapy to Combat Cancer ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26988985 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26988985 #FOAvip English Wikipedia <ref>{{Cite pmid|26988985}}</ref> Combining Epigenetic and Immune Therapy to Combat Cancer #MMPMID26988985 Chiappinelli KB; Zahnow CA; Ahuja N; Baylin SB Cancer Res 2016[Apr]; 76 (7): 1683-9 PMID26988985show ga The most exciting recent advance for achieving durable management of advanced human cancers is immune therapy, especially the concept of immune checkpoint blockade. However, with the exception of melanoma, most patients do not respond to immune therapy alone. A growing body of work has shown that epigenetic drugs, specifically DNA methyltransferase inhibitors, can upregulate immune signaling in epithelial cancer cells through demethylation of endogenous retroviruses and cancer testis antigens. These demethylating agents may induce T-cell attraction and enhance immune checkpoint inhibitor efficacy in mouse models. Current clinical trials are testing this combination therapy as a potent new cancer management strategy. äCombining Epigenetic and Immune Therapy to Combat Cancer (epmc).pdf DeepDyve Pubget Overpricing