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10.1111/j.1528-1167.2009.02273.x http://scihub22266oqcxt.onion/10.1111/j.1528-1167.2009.02273.x C4873278!4873278!19694791     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Epilepsia 2010 ; 51 (3): 423-31 Nephropedia Template TP {{tp|p=19694791|t=2010. Antiepileptic drugs abolish ictal but not interictal epileptiform discharges in vitro |pdf=|usr=}}{{19694791}} gab.com Text Antiepileptic drugs abolish ictal but not interictal epileptiform discharges in vitro JO: Epilepsia http://www.kidney.de/pget.php?&tw=1&pmid=19694791 #FOAvip Purpose: We established the effects of the antiepileptic drugs (AEDs) carbamazepine (CBZ), topiramate (TPM), and valproic acid (VPA) on the epileptiform activity induced by 4-aminopyridine (4AP) in the rat entorhinal cortex (EC) in an in vitro brain slice preparation. Methods: Brain slices were obtained from Sprague-Dawley rats (200?250 g). Field and intracellular recordings were made from the EC during bath application of 4AP (50 ?M). AEDs, and in some experiments, picrotoxin were bath applied concomitantly. Results: Prolonged (>3 s), ictal-like epileptiform events were abolished by CBZ (50 ?M), TPM (50 ?M), and VPA (1 mM), whereas shorter (<3 s) interictal-like discharges continued to occur, even at concentrations up to 4-fold as high. ?-Aminobutyric acid (GABA)A?receptor antagonism changed the 4AP-induced activity into recurrent interictal-like events that were not affected by CBZ or TPM, even at the highest concentrations. To establish whether these findings reflected the temporal features of the epileptiform discharges, we tested CBZ and TPM on 4AP-induced epileptiform activity driven by stimuli delivered at 100-, 10-, and 5-s intervals; these AEDs reduced ictal-like responses to stimuli at 100-s intervals at nearly therapeutic concentrations, but did not influence shorter interictal-like events elicited by stimuli delivered every 10 or 5 s. Conclusions: We conclude that the AED ability to control epileptiform synchronization in vitro depends mainly on activity-dependent characteristics such as discharge duration. Our data are in keeping with clinical evidence indicating that interictal activity is unaffected by AED levels that are effective to stop seizures. Twit Text FOAVip Antiepileptic drugs abolish ictal but not interictal epileptiform discharges in vitro ????Epilepsia http://www.kidney.de/pget.php?&tw=1&pmid=19694791 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19694791 #FOAvip English Wikipedia <ref>{{Cite pmid|19694791}}</ref> Antiepileptic drugs abolish ictal but not interictal epileptiform discharges in vitro #MMPMID19694791 D?Antuono M; Köhling R; Ricalzone S; Gotman J; Biagini G; Avoli M Epilepsia 2010[Mar]; 51 (3): 423-31 PMID19694791show ga Purpose: We established the effects of the antiepileptic drugs (AEDs) carbamazepine (CBZ), topiramate (TPM), and valproic acid (VPA) on the epileptiform activity induced by 4-aminopyridine (4AP) in the rat entorhinal cortex (EC) in an in vitro brain slice preparation. Methods: Brain slices were obtained from Sprague-Dawley rats (200?250 g). Field and intracellular recordings were made from the EC during bath application of 4AP (50 ?M). AEDs, and in some experiments, picrotoxin were bath applied concomitantly. Results: Prolonged (>3 s), ictal-like epileptiform events were abolished by CBZ (50 ?M), TPM (50 ?M), and VPA (1 mM), whereas shorter (<3 s) interictal-like discharges continued to occur, even at concentrations up to 4-fold as high. ?-Aminobutyric acid (GABA)A?receptor antagonism changed the 4AP-induced activity into recurrent interictal-like events that were not affected by CBZ or TPM, even at the highest concentrations. To establish whether these findings reflected the temporal features of the epileptiform discharges, we tested CBZ and TPM on 4AP-induced epileptiform activity driven by stimuli delivered at 100-, 10-, and 5-s intervals; these AEDs reduced ictal-like responses to stimuli at 100-s intervals at nearly therapeutic concentrations, but did not influence shorter interictal-like events elicited by stimuli delivered every 10 or 5 s. Conclusions: We conclude that the AED ability to control epileptiform synchronization in vitro depends mainly on activity-dependent characteristics such as discharge duration. Our data are in keeping with clinical evidence indicating that interictal activity is unaffected by AED levels that are effective to stop seizures. äAntiepileptic drugs abolish ictal but not interictal epileptiform disc(epmc).pdf DeepDyve Pubget Overpricing