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10.18632/oncotarget.7007 http://scihub22266oqcxt.onion/10.18632/oncotarget.7007 C4872787!4872787 !26824417     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26824417 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (6 ): 7307-17 Nephropedia Template TP {{tp|p=26824417 |t=2016. IL-32? inhibits stemness and epithelial-mesenchymal transition of cancer stem cells via the STAT3 pathway in colon cancer |pdf=|usr=}}{{26824417 }} gab.com Text IL-32 inhibits stemness and epithelial-mesenchymal transition of cancer stem cells via the STAT3 pathway in colon cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26824417 #FOAvip Interleukin (IL)-32 is a well-known cytokine associated with inflammation, virus infections and cancer. IL-32? is a newly identified isoform of IL-32, whose function has yet to be elucidated. In this study, we investigated IL-32? function in colon cancer stem cells. Using samples from colon cancer patients, we found that the expression of IL-32? mRNAs was significantly suppressed in tumor regions. We investigated the effects of IL-32? on colon cancer. Ectopic expression of IL-32? attenuated invasion, migration in vitro and in vivo tumorigenicity of colon cancer cells. IL-32? inhibited epithelial-mesenchymal transition (EMT), resulting in the suppression of their migratory and invasive capabilities of HT29 colon cancer cells. In addition, IL-32? altered various properties of CSCs, including sphere formation and expression of stemness related genes. IL-32? directly bound to STAT3 and inhibited its nuclear translocation, leading to inhibited transcription of downstream factors, including Bmi1 and ZEB1. We showed that IL-32? inhibited the STAT3-ZEB1 pathway and consequently inhibited key factors of stemness and EMT. Taken together, our findings reveal that IL-32? can be a tumor suppressor, indicating that IL-32? could possibly be used in therapies for colon cancer. Twit Text FOAVip IL-32 inhibits stemness and epithelial-mesenchymal transition of cancer stem cells via the STAT3 pathway in colon cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26824417 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26824417 #FOAvip English Wikipedia <ref>{{Cite pmid|26824417 }}</ref> IL-32? inhibits stemness and epithelial-mesenchymal transition of cancer stem cells via the STAT3 pathway in colon cancer #MMPMID26824417 Bak Y ; Kwon T ; Bak IS ; Hong J ; Yu DY ; Yoon DY Oncotarget 2016[Feb]; 7 (6 ): 7307-17 PMID26824417 show ga Interleukin (IL)-32 is a well-known cytokine associated with inflammation, virus infections and cancer. IL-32? is a newly identified isoform of IL-32, whose function has yet to be elucidated. In this study, we investigated IL-32? function in colon cancer stem cells. Using samples from colon cancer patients, we found that the expression of IL-32? mRNAs was significantly suppressed in tumor regions. We investigated the effects of IL-32? on colon cancer. Ectopic expression of IL-32? attenuated invasion, migration in vitro and in vivo tumorigenicity of colon cancer cells. IL-32? inhibited epithelial-mesenchymal transition (EMT), resulting in the suppression of their migratory and invasive capabilities of HT29 colon cancer cells. In addition, IL-32? altered various properties of CSCs, including sphere formation and expression of stemness related genes. IL-32? directly bound to STAT3 and inhibited its nuclear translocation, leading to inhibited transcription of downstream factors, including Bmi1 and ZEB1. We showed that IL-32? inhibited the STAT3-ZEB1 pathway and consequently inhibited key factors of stemness and EMT. Taken together, our findings reveal that IL-32? can be a tumor suppressor, indicating that IL-32? could possibly be used in therapies for colon cancer. |*Epithelial-Mesenchymal Transition [MESH] |Animals [MESH] |Apoptosis [MESH] |Blotting, Western [MESH] |Cell Movement [MESH] |Cell Proliferation [MESH] |Colonic Neoplasms/genetics/metabolism/*pathology [MESH] |Female [MESH] |Fluorescent Antibody Technique [MESH] |Follow-Up Studies [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Immunoenzyme Techniques [MESH] |Interleukins/genetics/*metabolism [MESH] |Lymphatic Metastasis [MESH] |Male [MESH] |Mice [MESH] |Mice, Nude [MESH] |Middle Aged [MESH] |Neoplasm Invasiveness [MESH] |Neoplasm Recurrence, Local/genetics/metabolism/*pathology [MESH] |Neoplasm Staging [MESH] |Neoplastic Stem Cells/metabolism/*pathology [MESH] |Prognosis [MESH] |RNA, Messenger/genetics [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |STAT3 Transcription Factor/genetics/*metabolism [MESH] |Tumor Cells, Cultured [MESH]IL-32? inhibits stemness and epithelial-mesenchymal transition of canc(epmc).pdf DeepDyve Pubget Overpricing