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10.18632/oncotarget.6841 http://scihub22266oqcxt.onion/10.18632/oncotarget.6841 C4872727!4872727 !26771136     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26771136 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (6 ): 6460-75 Nephropedia Template TP {{tp|p=26771136 |t=2016. Hierarchical regulation of the genome: global changes in nucleosome organization potentiate genome response |pdf=|usr=}}{{26771136 }} gab.com Text Hierarchical regulation of the genome: global changes in nucleosome organization potentiate genome response JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26771136 #FOAvip Nucleosome occupancy is critically important in regulating access to the eukaryotic genome. Few studies in human cells have measured genome-wide nucleosome distributions at high temporal resolution during a response to a common stimulus. We measured nucleosome distributions at high temporal resolution following Kaposi's-sarcoma-associated herpesvirus (KSHV) reactivation using our newly developed mTSS-seq technology, which maps nucleosome distribution at the transcription start sites (TSS) of all human genes. Nucleosomes underwent widespread changes in organization 24 hours after KSHV reactivation and returned to their basal nucleosomal architecture 48 hours after KSHV reactivation. The widespread changes consisted of an indiscriminate remodeling event resulting in the loss of nucleosome rotational phasing signals. Additionally, one in six TSSs in the human genome possessed nucleosomes that are translationally remodeled. 72% of the loci with translationally remodeled nucleosomes have nucleosomes that moved to positions encoded by the underlying DNA sequence. Finally we demonstrated that these widespread alterations in nucleosomal architecture potentiated regulatory factor binding. These descriptions of nucleosomal architecture changes provide a new framework for understanding the role of chromatin in the genomic response, and have allowed us to propose a hierarchical model for chromatin-based regulation of genome response. Twit Text FOAVip Hierarchical regulation of the genome: global changes in nucleosome organization potentiate genome response ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26771136 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26771136 #FOAvip English Wikipedia <ref>{{Cite pmid|26771136 }}</ref> Hierarchical regulation of the genome: global changes in nucleosome organization potentiate genome response #MMPMID26771136 Sexton BS ; Druliner BR ; Vera DL ; Avey D ; Zhu F ; Dennis JH Oncotarget 2016[Feb]; 7 (6 ): 6460-75 PMID26771136 show ga Nucleosome occupancy is critically important in regulating access to the eukaryotic genome. Few studies in human cells have measured genome-wide nucleosome distributions at high temporal resolution during a response to a common stimulus. We measured nucleosome distributions at high temporal resolution following Kaposi's-sarcoma-associated herpesvirus (KSHV) reactivation using our newly developed mTSS-seq technology, which maps nucleosome distribution at the transcription start sites (TSS) of all human genes. Nucleosomes underwent widespread changes in organization 24 hours after KSHV reactivation and returned to their basal nucleosomal architecture 48 hours after KSHV reactivation. The widespread changes consisted of an indiscriminate remodeling event resulting in the loss of nucleosome rotational phasing signals. Additionally, one in six TSSs in the human genome possessed nucleosomes that are translationally remodeled. 72% of the loci with translationally remodeled nucleosomes have nucleosomes that moved to positions encoded by the underlying DNA sequence. Finally we demonstrated that these widespread alterations in nucleosomal architecture potentiated regulatory factor binding. These descriptions of nucleosomal architecture changes provide a new framework for understanding the role of chromatin in the genomic response, and have allowed us to propose a hierarchical model for chromatin-based regulation of genome response. |*Gene Expression Regulation [MESH] |Chromatin/*genetics [MESH] |Chromosome Positioning [MESH] |Chromosomes, Human/*genetics [MESH] |Genome, Human/*genetics [MESH] |Herpesviridae Infections/*genetics/virology [MESH] |Herpesvirus 8, Human [MESH] |High-Throughput Nucleotide Sequencing [MESH] |Humans [MESH] |Nucleosomes/*genetics [MESH] |Protein Binding [MESH] |Transcription Factors [MESH] |Transcription Initiation Site [MESH]Hierarchical regulation of the genome: global changes in nucleosome or(epmc).pdf DeepDyve Pubget Overpricing